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- W1522801971 abstract "p130Cas (Cas) is a docking protein that becomes tyrosine phosphorylated in v-Src- or v-Crk-transformed cells and in integrin-stimulated cells. Cas −/− fibroblasts show defects in stress fiber formation, cell spreading, cell migration, and transformation by activated Src. To further characterize the role of Cas in signaling, we compared the expression profile in Cas −/− fibroblasts with that in Cas-re-expressing fibroblasts using the microarray methods. In Cas −/− fibroblasts, the expression of heme oxygenase 1 and caveolin-1 was reduced, but the expression of procollagen 1 α 1, procollagen 3 α 1, procollagen 11 α 1, elastin, periostin, TSC-36, and MARCKS was enhanced. The domains in Cas necessary for the change varied among these genes. Activated Src reduced the expression of most of these genes both in Cas −/− and in Cas +/+ fibroblasts. These results suggest the existence of signaling pathways that emanate from Cas to gene expression." @default.
- W1522801971 created "2016-06-24" @default.
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- W1522801971 date "2002-06-01" @default.
- W1522801971 modified "2023-09-29" @default.
- W1522801971 title "Analysis of gene expression profile in p130Cas-deficient fibroblasts" @default.
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- W1522801971 doi "https://doi.org/10.1016/s0006-291x(02)00527-2" @default.
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