Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522804078> ?p ?o ?g. }
- W1522804078 endingPage "33" @default.
- W1522804078 startingPage "17" @default.
- W1522804078 abstract "Recent upsurge in research has uncovered distinct circuitries that regulate appetite, energy expenditure and fat accrual under the supervision of hormonal feedback signalling of adipocyte leptin and gastric ghrelin in the hypothalamic integration of energy homeostasis. A host of messenger molecules of diverse chemical composition and origin mediate the crosstalk between the three circuitries. Leptin is now recognized as the mandatory afferent signal in maintenance of weight homeostasis. Leptin insufficiency in the hypothalamus due to diminished transport of leptin across the blood–brain barrier (BBB) imposed by environmental causes, such as consumption of energy-enriched diets and diminished energy expenditure, orchestrates unregulated fat accrual and the attendant disease cluster of metabolic syndrome. Bioavailability of leptin selectively in the hypothalamic targets with the aid of gene therapy successfully averted the environmentally induced metabolic afflictions and normalized lifespan. Thus, sustenance of optimal sufficiency in leptin signalling solely in the hypothalamus is a novel strategy to combat the worldwide epidemic of obesity and metabolic syndrome." @default.
- W1522804078 created "2016-06-24" @default.
- W1522804078 creator A5047037088 @default.
- W1522804078 creator A5084980664 @default.
- W1522804078 date "2010-01-01" @default.
- W1522804078 modified "2023-09-27" @default.
- W1522804078 title "Neuroendocrine Control of Energy Homeostasis: Update on New Insights" @default.
- W1522804078 cites W10086402 @default.
- W1522804078 cites W1492183417 @default.
- W1522804078 cites W1492605893 @default.
- W1522804078 cites W1512875938 @default.
- W1522804078 cites W1617674044 @default.
- W1522804078 cites W1631449371 @default.
- W1522804078 cites W1963558494 @default.
- W1522804078 cites W1966135415 @default.
- W1522804078 cites W1968877694 @default.
- W1522804078 cites W1972835121 @default.
- W1522804078 cites W1973418987 @default.
- W1522804078 cites W1974048755 @default.
- W1522804078 cites W1980710373 @default.
- W1522804078 cites W1981415589 @default.
- W1522804078 cites W1981744354 @default.
- W1522804078 cites W1986357169 @default.
- W1522804078 cites W1988357092 @default.
- W1522804078 cites W1990237147 @default.
- W1522804078 cites W1991751082 @default.
- W1522804078 cites W1996713062 @default.
- W1522804078 cites W2003967044 @default.
- W1522804078 cites W2006151773 @default.
- W1522804078 cites W2006675180 @default.
- W1522804078 cites W2012490357 @default.
- W1522804078 cites W2016392763 @default.
- W1522804078 cites W2016678466 @default.
- W1522804078 cites W2018995675 @default.
- W1522804078 cites W2025898073 @default.
- W1522804078 cites W2026650454 @default.
- W1522804078 cites W2030130108 @default.
- W1522804078 cites W2031239093 @default.
- W1522804078 cites W2032668395 @default.
- W1522804078 cites W2033708226 @default.
- W1522804078 cites W2033892184 @default.
- W1522804078 cites W2034697008 @default.
- W1522804078 cites W2034757128 @default.
- W1522804078 cites W2039635333 @default.
- W1522804078 cites W2040328785 @default.
- W1522804078 cites W2040750053 @default.
- W1522804078 cites W2041624270 @default.
- W1522804078 cites W2042363320 @default.
- W1522804078 cites W2042535492 @default.
- W1522804078 cites W2043549778 @default.
- W1522804078 cites W2045924832 @default.
- W1522804078 cites W2047376228 @default.
- W1522804078 cites W2047959796 @default.
- W1522804078 cites W2050252451 @default.
- W1522804078 cites W2051533287 @default.
- W1522804078 cites W2051889648 @default.
- W1522804078 cites W2052528853 @default.
- W1522804078 cites W2056463729 @default.
- W1522804078 cites W2064611710 @default.
- W1522804078 cites W2065112278 @default.
- W1522804078 cites W2069733431 @default.
- W1522804078 cites W2071438225 @default.
- W1522804078 cites W2073550407 @default.
- W1522804078 cites W2075353539 @default.
- W1522804078 cites W2075677382 @default.
- W1522804078 cites W2075690247 @default.
- W1522804078 cites W2076499590 @default.
- W1522804078 cites W2076743992 @default.
- W1522804078 cites W2078511984 @default.
- W1522804078 cites W2078753928 @default.
- W1522804078 cites W2079503496 @default.
- W1522804078 cites W2080139868 @default.
- W1522804078 cites W2080508995 @default.
- W1522804078 cites W2081377230 @default.
- W1522804078 cites W2082711999 @default.
- W1522804078 cites W2087174791 @default.
- W1522804078 cites W2088593927 @default.
- W1522804078 cites W2092207134 @default.
- W1522804078 cites W2092518754 @default.
- W1522804078 cites W2092625960 @default.
- W1522804078 cites W2097378006 @default.
- W1522804078 cites W2101391305 @default.
- W1522804078 cites W2101782891 @default.
- W1522804078 cites W2103506162 @default.
- W1522804078 cites W2114578598 @default.
- W1522804078 cites W2116843182 @default.
- W1522804078 cites W2119178339 @default.
- W1522804078 cites W2120305090 @default.
- W1522804078 cites W2122301924 @default.
- W1522804078 cites W2126380907 @default.
- W1522804078 cites W2128837130 @default.
- W1522804078 cites W2129666112 @default.
- W1522804078 cites W2134554776 @default.
- W1522804078 cites W2136099456 @default.
- W1522804078 cites W2136690411 @default.
- W1522804078 cites W2137619386 @default.
- W1522804078 cites W2141060229 @default.
- W1522804078 cites W2148588126 @default.