FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522828518> ?p ?o ?g. }

• W1522828518 endingPage "219" @default.
• W1522828518 startingPage "209" @default.
• W1522828518 abstract "Novosphingobium aromaticivorans , a unique ubiquitous bacterium that metabolizes xenobiotics and activates environmental estrogens, has been suggested as a pathogenic factor in the development of primary biliary cirrhosis (PBC). To define the molecular basis of PBC sera reactivity, we investigated the characteristic of the bacterial antigens involved. We cloned and sequenced four genes from N. aromaticivorans coding for immunoreactive proteins, arbitrarily named Novo 1 through Novo 4. We subsequently analyzed these proteins for their homology to known mitochondrial proteins and defined their reactivity using monoclonal antibodies (mAbs), rabbit anti-lipoic acid antibody, and PBC/control sera. Moreover, we studied their phylogenetic relation with the known PBC autoantigens. Novo proteins have an extraordinary degree of amino acid homology with all of the major human mitochondrial autoantigens PDC-E2 (Novo 1 and 2), OGDC-E2 (Novo 3), and BCOADC-E2 (Novo 4). Moreover, Novo 1–4 contain a lipoylated domain, are recognized by AMA-positive sera, and react with specific mAbs to mitochondrial antigens. Interestingly, the phylogenetic relation of the proteins emphasizes the conservation of the lipoylated domain. In conclusion, our data provide a high degree of confidence that N. aromaticivorans may potentiate the breakdown of self tolerance in genetically susceptible individuals." @default.
• W1522828518 created "2016-06-24" @default.
• W1522828518 creator A5003030575 @default.
• W1522828518 creator A5016645912 @default.
• W1522828518 creator A5020774708 @default.
• W1522828518 creator A5035953102 @default.
• W1522828518 creator A5041092935 @default.
• W1522828518 creator A5041565503 @default.
• W1522828518 creator A5063256255 @default.
• W1522828518 creator A5069076072 @default.
• W1522828518 date "2005-05-01" @default.
• W1522828518 modified "2023-10-18" @default.
• W1522828518 title "Phylogenetic and immunological definition of four lipoylated proteins from , implications for primary biliary cirrhosis" @default.
• W1522828518 cites W119672920 @default.
• W1522828518 cites W1956131600 @default.
• W1522828518 cites W1967147772 @default.
• W1522828518 cites W1983375163 @default.
• W1522828518 cites W1986803775 @default.
• W1522828518 cites W2026531998 @default.
• W1522828518 cites W2043802593 @default.
• W1522828518 cites W2044009781 @default.
• W1522828518 cites W2044119777 @default.
• W1522828518 cites W2049707317 @default.
• W1522828518 cites W2054664696 @default.
• W1522828518 cites W2074202083 @default.
• W1522828518 cites W2076118745 @default.
• W1522828518 cites W2080938189 @default.
• W1522828518 cites W2083558097 @default.
• W1522828518 cites W2084880276 @default.
• W1522828518 cites W2089771934 @default.
• W1522828518 cites W2097411417 @default.
• W1522828518 cites W2100684647 @default.
• W1522828518 cites W2121126495 @default.
• W1522828518 cites W2143472546 @default.
• W1522828518 cites W2146758409 @default.
• W1522828518 cites W2148082560 @default.
• W1522828518 cites W2148935965 @default.
• W1522828518 cites W2151434633 @default.
• W1522828518 cites W2152474063 @default.
• W1522828518 cites W2155524887 @default.
• W1522828518 cites W2159434940 @default.
• W1522828518 cites W2160005035 @default.
• W1522828518 cites W2162354645 @default.
• W1522828518 cites W2170299305 @default.
• W1522828518 cites W2254283806 @default.
• W1522828518 cites W2735817229 @default.
• W1522828518 cites W78569768 @default.
• W1522828518 doi "https://doi.org/10.1016/j.jaut.2005.01.012" @default.
• W1522828518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15848043" @default.
• W1522828518 hasPublicationYear "2005" @default.
• W1522828518 type Work @default.
• W1522828518 sameAs 1522828518 @default.
• W1522828518 citedByCount "93" @default.
• W1522828518 countsByYear W15228285182012 @default.
• W1522828518 countsByYear W15228285182013 @default.
• W1522828518 countsByYear W15228285182014 @default.
• W1522828518 countsByYear W15228285182015 @default.
• W1522828518 countsByYear W15228285182016 @default.
• W1522828518 countsByYear W15228285182017 @default.
• W1522828518 countsByYear W15228285182018 @default.
• W1522828518 countsByYear W15228285182019 @default.
• W1522828518 countsByYear W15228285182020 @default.
• W1522828518 countsByYear W15228285182021 @default.
• W1522828518 countsByYear W15228285182023 @default.
• W1522828518 crossrefType "journal-article" @default.
• W1522828518 hasAuthorship W1522828518A5003030575 @default.
• W1522828518 hasAuthorship W1522828518A5016645912 @default.
• W1522828518 hasAuthorship W1522828518A5020774708 @default.
• W1522828518 hasAuthorship W1522828518A5035953102 @default.
• W1522828518 hasAuthorship W1522828518A5041092935 @default.
• W1522828518 hasAuthorship W1522828518A5041565503 @default.
• W1522828518 hasAuthorship W1522828518A5063256255 @default.
• W1522828518 hasAuthorship W1522828518A5069076072 @default.
• W1522828518 hasConcept C104317684 @default.
• W1522828518 hasConcept C153911025 @default.
• W1522828518 hasConcept C165525559 @default.
• W1522828518 hasConcept C193252679 @default.
• W1522828518 hasConcept C203014093 @default.
• W1522828518 hasConcept C2780366471 @default.
• W1522828518 hasConcept C54355233 @default.
• W1522828518 hasConcept C86803240 @default.
• W1522828518 hasConceptScore W1522828518C104317684 @default.
• W1522828518 hasConceptScore W1522828518C153911025 @default.
• W1522828518 hasConceptScore W1522828518C165525559 @default.
• W1522828518 hasConceptScore W1522828518C193252679 @default.
• W1522828518 hasConceptScore W1522828518C203014093 @default.
• W1522828518 hasConceptScore W1522828518C2780366471 @default.
• W1522828518 hasConceptScore W1522828518C54355233 @default.
• W1522828518 hasConceptScore W1522828518C86803240 @default.
• W1522828518 hasIssue "3" @default.
• W1522828518 hasLocation W15228285181 @default.
• W1522828518 hasLocation W15228285182 @default.
• W1522828518 hasOpenAccess W1522828518 @default.
• W1522828518 hasPrimaryLocation W15228285181 @default.
• W1522828518 hasRelatedWork W1980942258 @default.
• W1522828518 hasRelatedWork W1981393315 @default.
• W1522828518 hasRelatedWork W1991471459 @default.
• W1522828518 hasRelatedWork W2045313050 @default.

• next