FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522880877> ?p ?o ?g. }

• W1522880877 endingPage "40" @default.
• W1522880877 startingPage "1" @default.
• W1522880877 abstract "Amyloid proteins, mainly including amyloid-β peptides, prion proteins, α-synuclein, copper/zinc superoxide dismutase, as well as the bacterial protein RepA, are characterized by the deposition in a variety of tissues or cells as aggregated species (amyloids or insoluble deposits or inclusions) that share a distinctive β-sheet-rich fibrillar ultrastructure. Although the amyloid is predominantly proteinaceous, careful examination of disease tissues and cells has revealed the presence of a significant quantity of polyanionic species including nucleic acids and polysaccharides associated with the amyloid. For example, in the brain tissues from victims of Alzheimer's disease, nucleic acids have been detected in neurofibrillary tangles and intracellular inclusions primarily composed of the tau protein, as well as in senile plaques composed of the amyloid-β peptides. Therefore, much effort has been directed to understanding the roles of the ubiquitous polyanionic species such as nucleic acids in the aggregation of amyloid proteins. Increasing evidence indicates that the amyloid proteins exhibit a high binding affinity for nucleic acids and the binding is mainly driven by electrostatic interactions between both. The association with nucleic acids leads to significant variations of the amyloid proteins in conformation. The nucleic acids have been observed to be capable of significantly inducing and accelerating the aggregation of amyloid proteins likely through a template effect. The template effect could restrict the orientations of amyloid proteins along nucleic acid strands and increase the local concentrations of amyloid proteins on nucleic acid surfaces, leading to enhancement in the intermolecular hydrophobic contacts of amyloid proteins. The nucleic acids have also been found to occur as an intrinsic or transient component in the resulted proteinaceous aggregates." @default.
• W1522880877 created "2016-06-24" @default.
• W1522880877 creator A5064222660 @default.
• W1522880877 creator A5083291754 @default.
• W1522880877 date "2011-01-01" @default.
• W1522880877 modified "2023-09-26" @default.
• W1522880877 title "Nucleic acid-mediated protein aggregation and assembly" @default.
• W1522880877 cites W1591724033 @default.
• W1522880877 cites W1619082318 @default.
• W1522880877 cites W1966130903 @default.
• W1522880877 cites W1966691229 @default.
• W1522880877 cites W1966822199 @default.
• W1522880877 cites W1968325427 @default.
• W1522880877 cites W1969008792 @default.
• W1522880877 cites W1969941075 @default.
• W1522880877 cites W1970357999 @default.
• W1522880877 cites W1972072787 @default.
• W1522880877 cites W1973140768 @default.
• W1522880877 cites W1980825524 @default.
• W1522880877 cites W1981458656 @default.
• W1522880877 cites W1984876762 @default.
• W1522880877 cites W1985476822 @default.
• W1522880877 cites W1986105957 @default.
• W1522880877 cites W1986196133 @default.
• W1522880877 cites W1992084965 @default.
• W1522880877 cites W1993319890 @default.
• W1522880877 cites W1996146314 @default.
• W1522880877 cites W1997973599 @default.
• W1522880877 cites W2001882535 @default.
• W1522880877 cites W2003237575 @default.
• W1522880877 cites W2003419081 @default.
• W1522880877 cites W2005595315 @default.
• W1522880877 cites W2009556855 @default.
• W1522880877 cites W2010705328 @default.
• W1522880877 cites W2013021944 @default.
• W1522880877 cites W2013679718 @default.
• W1522880877 cites W2014290130 @default.
• W1522880877 cites W2018146408 @default.
• W1522880877 cites W2019041725 @default.
• W1522880877 cites W2019326808 @default.
• W1522880877 cites W2021639930 @default.
• W1522880877 cites W2021785060 @default.
• W1522880877 cites W2021977313 @default.
• W1522880877 cites W2022794788 @default.
• W1522880877 cites W2024423815 @default.
• W1522880877 cites W2025707488 @default.
• W1522880877 cites W2033576141 @default.
• W1522880877 cites W2033796334 @default.
• W1522880877 cites W2033843609 @default.
• W1522880877 cites W2034120336 @default.
• W1522880877 cites W2034268042 @default.
• W1522880877 cites W2034289842 @default.
• W1522880877 cites W2034798093 @default.
• W1522880877 cites W2034806764 @default.
• W1522880877 cites W2036854945 @default.
• W1522880877 cites W2040351396 @default.
• W1522880877 cites W2044242760 @default.
• W1522880877 cites W2046014998 @default.
• W1522880877 cites W2046518122 @default.
• W1522880877 cites W2053097655 @default.
• W1522880877 cites W2053164047 @default.
• W1522880877 cites W2057579163 @default.
• W1522880877 cites W2057682957 @default.
• W1522880877 cites W2061204975 @default.
• W1522880877 cites W2061627162 @default.
• W1522880877 cites W2063139087 @default.
• W1522880877 cites W2066254237 @default.
• W1522880877 cites W2067540111 @default.
• W1522880877 cites W2072687635 @default.
• W1522880877 cites W2073488873 @default.
• W1522880877 cites W2073864172 @default.
• W1522880877 cites W2074649216 @default.
• W1522880877 cites W2077044335 @default.
• W1522880877 cites W2078666749 @default.
• W1522880877 cites W2081812447 @default.
• W1522880877 cites W2081926649 @default.
• W1522880877 cites W2082790220 @default.
• W1522880877 cites W2086272648 @default.
• W1522880877 cites W2087063587 @default.
• W1522880877 cites W2087294184 @default.
• W1522880877 cites W2089735758 @default.
• W1522880877 cites W2093713022 @default.
• W1522880877 cites W2093983981 @default.
• W1522880877 cites W2095851154 @default.
• W1522880877 cites W2097228496 @default.
• W1522880877 cites W2103997070 @default.
• W1522880877 cites W2109022553 @default.
• W1522880877 cites W2110418449 @default.
• W1522880877 cites W2110888808 @default.
• W1522880877 cites W2116215891 @default.
• W1522880877 cites W2123779560 @default.
• W1522880877 cites W2128815118 @default.
• W1522880877 cites W2130352925 @default.
• W1522880877 cites W2131268268 @default.
• W1522880877 cites W2131769962 @default.
• W1522880877 cites W2138468217 @default.
• W1522880877 cites W2141149420 @default.
• W1522880877 cites W2143830585 @default.

• next