Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522941314> ?p ?o ?g. }
- W1522941314 endingPage "2009" @default.
- W1522941314 startingPage "1999" @default.
- W1522941314 abstract "Retinoic acid related orphan receptor gamma-t (RORγt) is known to be a master regulator of Th17-cell development. In this study, we generated RORγt-overexpressing transgenic (RORγt Tg) mice in which transgene expression was driven by the CD2 promoter, and found that these mice developed polyclonal plasmacytosis and autoantibody production. RORγt Tg mice were generated on a C57BL/6 background, and also were intercrossed with BALB/c mice. BALB/c F1 (BALB/F1) RORγt Tg mice developed massive polyclonal plasma-cytosis, and had shorter life spans. Splenomegaly and infiltration of plasma cells into the lung were observed. Hyperglobulinemia, anti-double-stranded DNA antibodies, anti-erythrocyte antibodies, and anti-platelet antibodies were detected in BALB/F1 RORγt Tg mice. In the present study, polyclonal plasmacytosis in BALB/F1 RORγt Tg mice appeared to be due to the induction of excessive IL-6 production by IL-17. We detected increased numbers of CD11b(+) cells that produced IL-6. We also generatedIL-6-deficient RORγt Tg BALB/F1 background mice, which displayed high levels of serum IL-17, but did not develop severe hyperglobulinemia. Excessive IL-6 production by several cell types, including macrophages, in BALB/F1 RORγt Tg mice, might effect the development of plasma-cytosis. These results suggest that RORγt plays important roles in the development of plasmacytosis and autoantibody production." @default.
- W1522941314 created "2016-06-24" @default.
- W1522941314 creator A5001514470 @default.
- W1522941314 creator A5006709520 @default.
- W1522941314 creator A5010836878 @default.
- W1522941314 creator A5018049490 @default.
- W1522941314 creator A5025252306 @default.
- W1522941314 creator A5036614400 @default.
- W1522941314 creator A5036684201 @default.
- W1522941314 creator A5037302980 @default.
- W1522941314 creator A5039619402 @default.
- W1522941314 creator A5041641555 @default.
- W1522941314 creator A5046543073 @default.
- W1522941314 creator A5052651716 @default.
- W1522941314 creator A5059978154 @default.
- W1522941314 creator A5079821787 @default.
- W1522941314 creator A5082957036 @default.
- W1522941314 creator A5083746251 @default.
- W1522941314 creator A5087982423 @default.
- W1522941314 creator A5088737569 @default.
- W1522941314 date "2012-07-09" @default.
- W1522941314 modified "2023-10-14" @default.
- W1522941314 title "Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice" @default.
- W1522941314 cites W1528942387 @default.
- W1522941314 cites W1576984763 @default.
- W1522941314 cites W1588339552 @default.
- W1522941314 cites W1942668068 @default.
- W1522941314 cites W1963689659 @default.
- W1522941314 cites W1979504896 @default.
- W1522941314 cites W1987628377 @default.
- W1522941314 cites W1989588757 @default.
- W1522941314 cites W2002817805 @default.
- W1522941314 cites W2007710827 @default.
- W1522941314 cites W2012706589 @default.
- W1522941314 cites W2014732115 @default.
- W1522941314 cites W2015735096 @default.
- W1522941314 cites W2017987372 @default.
- W1522941314 cites W2026611418 @default.
- W1522941314 cites W2047756822 @default.
- W1522941314 cites W2056320810 @default.
- W1522941314 cites W2060912271 @default.
- W1522941314 cites W2067761476 @default.
- W1522941314 cites W2069426612 @default.
- W1522941314 cites W2071642927 @default.
- W1522941314 cites W2086264253 @default.
- W1522941314 cites W2091451666 @default.
- W1522941314 cites W2106882037 @default.
- W1522941314 cites W2107235439 @default.
- W1522941314 cites W2111034338 @default.
- W1522941314 cites W2112866067 @default.
- W1522941314 cites W2142017607 @default.
- W1522941314 cites W2148662266 @default.
- W1522941314 cites W2151566115 @default.
- W1522941314 cites W2155779547 @default.
- W1522941314 cites W2160258620 @default.
- W1522941314 cites W2171571685 @default.
- W1522941314 cites W4237771960 @default.
- W1522941314 doi "https://doi.org/10.1002/eji.201142250" @default.
- W1522941314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22623033" @default.
- W1522941314 hasPublicationYear "2012" @default.
- W1522941314 type Work @default.
- W1522941314 sameAs 1522941314 @default.
- W1522941314 citedByCount "23" @default.
- W1522941314 countsByYear W15229413142013 @default.
- W1522941314 countsByYear W15229413142014 @default.
- W1522941314 countsByYear W15229413142015 @default.
- W1522941314 countsByYear W15229413142016 @default.
- W1522941314 countsByYear W15229413142017 @default.
- W1522941314 countsByYear W15229413142018 @default.
- W1522941314 countsByYear W15229413142019 @default.
- W1522941314 countsByYear W15229413142020 @default.
- W1522941314 countsByYear W15229413142021 @default.
- W1522941314 crossrefType "journal-article" @default.
- W1522941314 hasAuthorship W1522941314A5001514470 @default.
- W1522941314 hasAuthorship W1522941314A5006709520 @default.
- W1522941314 hasAuthorship W1522941314A5010836878 @default.
- W1522941314 hasAuthorship W1522941314A5018049490 @default.
- W1522941314 hasAuthorship W1522941314A5025252306 @default.
- W1522941314 hasAuthorship W1522941314A5036614400 @default.
- W1522941314 hasAuthorship W1522941314A5036684201 @default.
- W1522941314 hasAuthorship W1522941314A5037302980 @default.
- W1522941314 hasAuthorship W1522941314A5039619402 @default.
- W1522941314 hasAuthorship W1522941314A5041641555 @default.
- W1522941314 hasAuthorship W1522941314A5046543073 @default.
- W1522941314 hasAuthorship W1522941314A5052651716 @default.
- W1522941314 hasAuthorship W1522941314A5059978154 @default.
- W1522941314 hasAuthorship W1522941314A5079821787 @default.
- W1522941314 hasAuthorship W1522941314A5082957036 @default.
- W1522941314 hasAuthorship W1522941314A5083746251 @default.
- W1522941314 hasAuthorship W1522941314A5087982423 @default.
- W1522941314 hasAuthorship W1522941314A5088737569 @default.
- W1522941314 hasBestOaLocation W15229413141 @default.
- W1522941314 hasConcept C102230213 @default.
- W1522941314 hasConcept C104317684 @default.
- W1522941314 hasConcept C141035611 @default.
- W1522941314 hasConcept C153911025 @default.
- W1522941314 hasConcept C159654299 @default.
- W1522941314 hasConcept C163764329 @default.