Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522946871> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W1522946871 abstract "Abstract : The activity of estrogen receptor a is activated by both ligand binding and various modifications including phosphorylation and acetylation. Recently we have isolated a somatic ERalpha mutation which occurs in the major p300 acetylation site of ERalpha(Lys 303 to Arg, K303R)in human breast hyperplasias. This mutant is significantly correlated with both breast tumorigenesis and development. We report here that a component of the nucleosome remodeling and histone deacetylase complexes (NuRD), called metastasis-associated protein 1-like 1 (MTA1-L1),is an ERalpha binding protein both in vivo and in vitro. Also, we found that this interaction is ligand independent and requires the N-terminal region of MTA1-L1 and multiple domains of ER, Furthermore, we show that MTA1-L1 downregulates wild-type ERalpha, but not the K303R ERalpha mutation activities in transient transactivation assays. Taken together, our results suggest that the alterated ERalpha-containing NuRD function due to the K303R mutation could be a possible mechanism for this hypersensitive phenomenon." @default.
- W1522946871 created "2016-06-24" @default.
- W1522946871 creator A5018316352 @default.
- W1522946871 creator A5054255756 @default.
- W1522946871 date "2003-06-01" @default.
- W1522946871 modified "2023-09-26" @default.
- W1522946871 title "The Role of Estrogen Receptor alpha K303R Mutation in Breast Cancer Metastasis" @default.
- W1522946871 doi "https://doi.org/10.21236/ada417835" @default.
- W1522946871 hasPublicationYear "2003" @default.
- W1522946871 type Work @default.
- W1522946871 sameAs 1522946871 @default.
- W1522946871 citedByCount "0" @default.
- W1522946871 crossrefType "report" @default.
- W1522946871 hasAuthorship W1522946871A5018316352 @default.
- W1522946871 hasAuthorship W1522946871A5054255756 @default.
- W1522946871 hasConcept C104317684 @default.
- W1522946871 hasConcept C119157956 @default.
- W1522946871 hasConcept C121608353 @default.
- W1522946871 hasConcept C1292079 @default.
- W1522946871 hasConcept C172313692 @default.
- W1522946871 hasConcept C185592680 @default.
- W1522946871 hasConcept C501734568 @default.
- W1522946871 hasConcept C502942594 @default.
- W1522946871 hasConcept C530470458 @default.
- W1522946871 hasConcept C54355233 @default.
- W1522946871 hasConcept C64927066 @default.
- W1522946871 hasConcept C84606932 @default.
- W1522946871 hasConcept C86339819 @default.
- W1522946871 hasConcept C86803240 @default.
- W1522946871 hasConcept C95444343 @default.
- W1522946871 hasConceptScore W1522946871C104317684 @default.
- W1522946871 hasConceptScore W1522946871C119157956 @default.
- W1522946871 hasConceptScore W1522946871C121608353 @default.
- W1522946871 hasConceptScore W1522946871C1292079 @default.
- W1522946871 hasConceptScore W1522946871C172313692 @default.
- W1522946871 hasConceptScore W1522946871C185592680 @default.
- W1522946871 hasConceptScore W1522946871C501734568 @default.
- W1522946871 hasConceptScore W1522946871C502942594 @default.
- W1522946871 hasConceptScore W1522946871C530470458 @default.
- W1522946871 hasConceptScore W1522946871C54355233 @default.
- W1522946871 hasConceptScore W1522946871C64927066 @default.
- W1522946871 hasConceptScore W1522946871C84606932 @default.
- W1522946871 hasConceptScore W1522946871C86339819 @default.
- W1522946871 hasConceptScore W1522946871C86803240 @default.
- W1522946871 hasConceptScore W1522946871C95444343 @default.
- W1522946871 hasLocation W15229468711 @default.
- W1522946871 hasOpenAccess W1522946871 @default.
- W1522946871 hasPrimaryLocation W15229468711 @default.
- W1522946871 hasRelatedWork W1513936776 @default.
- W1522946871 hasRelatedWork W1965427954 @default.
- W1522946871 hasRelatedWork W1966320080 @default.
- W1522946871 hasRelatedWork W1970219055 @default.
- W1522946871 hasRelatedWork W1978981428 @default.
- W1522946871 hasRelatedWork W2003686815 @default.
- W1522946871 hasRelatedWork W2007534671 @default.
- W1522946871 hasRelatedWork W2055378709 @default.
- W1522946871 hasRelatedWork W2063437553 @default.
- W1522946871 hasRelatedWork W2072154601 @default.
- W1522946871 hasRelatedWork W2078168707 @default.
- W1522946871 hasRelatedWork W2088280645 @default.
- W1522946871 hasRelatedWork W2096007338 @default.
- W1522946871 hasRelatedWork W2098982859 @default.
- W1522946871 hasRelatedWork W2106204672 @default.
- W1522946871 hasRelatedWork W2107558077 @default.
- W1522946871 hasRelatedWork W2129383700 @default.
- W1522946871 hasRelatedWork W2135299222 @default.
- W1522946871 hasRelatedWork W2162799096 @default.
- W1522946871 hasRelatedWork W2166153112 @default.
- W1522946871 isParatext "false" @default.
- W1522946871 isRetracted "false" @default.
- W1522946871 magId "1522946871" @default.
- W1522946871 workType "report" @default.