Matches in SemOpenAlex for { <https://semopenalex.org/work/W1522961211> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1522961211 endingPage "3" @default.
- W1522961211 startingPage "400" @default.
- W1522961211 abstract "Deletion at 9p21 is frequent in many tumor types. A candidate tumor suppressor gene, p16INK4a, was mapped to this region and is frequently inactivated by several different mechanisms in many tumor types, including non-small cell lung cancer, but not in small cell lung cancer (SCLC). p16 functions as a cyclin/CDK inhibitor to prevent phosphorylation of pRB. It has been demonstrated that most SCLCs have lost pRB but retained p16, and the inactivation of pRB excludes the inactivation of p16 and vice versa. To determine the potential existence of other tumor suppressor genes on the short arm of chromosome 9 in SCLC, we tested 46 primary SCLCs by microsatellite analysis. We found that more than 89% of the tumors exhibited loss of heterozygosity (LOH) at 9p with three distinct minimal deleted areas. Among those areas, LOH at 9p21 was most frequent (86%), with a peak at a marker 150 kb telomeric to p16INK4a. LOH was also observed in more than 50% of the tumors at two other regions, 9p22 and 9p13. Our data strongly suggest the presence of at least three novel tumor suppressor loci on 9p in SCLC, and further investigations to clone candidate tumor suppressor genes are warranted." @default.
- W1522961211 created "2016-06-24" @default.
- W1522961211 creator A5010218106 @default.
- W1522961211 creator A5011271927 @default.
- W1522961211 creator A5020414083 @default.
- W1522961211 creator A5023135321 @default.
- W1522961211 creator A5027167033 @default.
- W1522961211 creator A5038749740 @default.
- W1522961211 creator A5048865240 @default.
- W1522961211 creator A5055974749 @default.
- W1522961211 creator A5085188591 @default.
- W1522961211 creator A5086583083 @default.
- W1522961211 date "1997-02-01" @default.
- W1522961211 modified "2023-09-23" @default.
- W1522961211 title "Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancer." @default.
- W1522961211 cites W2167779491 @default.
- W1522961211 cites W2266659593 @default.
- W1522961211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9012464" @default.
- W1522961211 hasPublicationYear "1997" @default.
- W1522961211 type Work @default.
- W1522961211 sameAs 1522961211 @default.
- W1522961211 citedByCount "26" @default.
- W1522961211 countsByYear W15229612112016 @default.
- W1522961211 countsByYear W15229612112018 @default.
- W1522961211 crossrefType "journal-article" @default.
- W1522961211 hasAuthorship W1522961211A5010218106 @default.
- W1522961211 hasAuthorship W1522961211A5011271927 @default.
- W1522961211 hasAuthorship W1522961211A5020414083 @default.
- W1522961211 hasAuthorship W1522961211A5023135321 @default.
- W1522961211 hasAuthorship W1522961211A5027167033 @default.
- W1522961211 hasAuthorship W1522961211A5038749740 @default.
- W1522961211 hasAuthorship W1522961211A5048865240 @default.
- W1522961211 hasAuthorship W1522961211A5055974749 @default.
- W1522961211 hasAuthorship W1522961211A5085188591 @default.
- W1522961211 hasAuthorship W1522961211A5086583083 @default.
- W1522961211 hasConcept C104317684 @default.
- W1522961211 hasConcept C121608353 @default.
- W1522961211 hasConcept C143589142 @default.
- W1522961211 hasConcept C153911025 @default.
- W1522961211 hasConcept C179185449 @default.
- W1522961211 hasConcept C180754005 @default.
- W1522961211 hasConcept C2778264664 @default.
- W1522961211 hasConcept C30481170 @default.
- W1522961211 hasConcept C502942594 @default.
- W1522961211 hasConcept C54355233 @default.
- W1522961211 hasConcept C555283112 @default.
- W1522961211 hasConcept C81089528 @default.
- W1522961211 hasConcept C86803240 @default.
- W1522961211 hasConceptScore W1522961211C104317684 @default.
- W1522961211 hasConceptScore W1522961211C121608353 @default.
- W1522961211 hasConceptScore W1522961211C143589142 @default.
- W1522961211 hasConceptScore W1522961211C153911025 @default.
- W1522961211 hasConceptScore W1522961211C179185449 @default.
- W1522961211 hasConceptScore W1522961211C180754005 @default.
- W1522961211 hasConceptScore W1522961211C2778264664 @default.
- W1522961211 hasConceptScore W1522961211C30481170 @default.
- W1522961211 hasConceptScore W1522961211C502942594 @default.
- W1522961211 hasConceptScore W1522961211C54355233 @default.
- W1522961211 hasConceptScore W1522961211C555283112 @default.
- W1522961211 hasConceptScore W1522961211C81089528 @default.
- W1522961211 hasConceptScore W1522961211C86803240 @default.
- W1522961211 hasIssue "3" @default.
- W1522961211 hasLocation W15229612111 @default.
- W1522961211 hasOpenAccess W1522961211 @default.
- W1522961211 hasPrimaryLocation W15229612111 @default.
- W1522961211 hasRelatedWork W1422708495 @default.
- W1522961211 hasRelatedWork W1522961211 @default.
- W1522961211 hasRelatedWork W1994684460 @default.
- W1522961211 hasRelatedWork W2043315458 @default.
- W1522961211 hasRelatedWork W2160262772 @default.
- W1522961211 hasRelatedWork W2197445941 @default.
- W1522961211 hasRelatedWork W2382751894 @default.
- W1522961211 hasRelatedWork W2421904573 @default.
- W1522961211 hasRelatedWork W2515714979 @default.
- W1522961211 hasRelatedWork W4248183732 @default.
- W1522961211 hasVolume "57" @default.
- W1522961211 isParatext "false" @default.
- W1522961211 isRetracted "false" @default.
- W1522961211 magId "1522961211" @default.
- W1522961211 workType "article" @default.