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- W1523008223 abstract "Publisher Summary This chapter focuses on adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system (CNS). The recombinant adeno-associated virus (rAAV) vector system incorporates features that make it a good choice for in vivo research. These features include efficient and long-term gene expression in a broad range of organs that appears to be well tolerated by laboratory animals. The brain is a, particularly good target for viral vector approaches because of the topic maps of neuroanatomical organization. Wild-type AAV infection commonly occurs early in life, and up to 80% of the human population is seropositive for AAV. AAV is a dependovirus requiring a helper virus to complete its life cycle. Apart from gene therapy applications, in vivo rAAV somatic cell gene transfer is likely to be useful for disease modeling. The pathology of Parkinson's disease is characterized by movement disorders concomitant with the degeneration of dopaminergic neurons in the substantia nigra and their axons in the striatum. Alzheimer's disease is, in part, a cholinergic deficit supported by the role of the neurotransmitter acetylcholine in memory function." @default.
- W1523008223 created "2016-06-24" @default.
- W1523008223 creator A5009699237 @default.
- W1523008223 creator A5019848579 @default.
- W1523008223 creator A5064494707 @default.
- W1523008223 date "2000-01-01" @default.
- W1523008223 modified "2023-09-24" @default.
- W1523008223 title "Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system" @default.
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