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- W1523160355 abstract "To determine whether offspring of centenarians acquired protection from age-related diseases.Case-control study.The study was part of the Longevity Genes Project at Albert Einstein College of Medicine.Centenarians (n=145), offspring of centenarians (n=180), and spouses of the offspring of centenarians (n=75) as a control group. Two additional groups served as controls: age-matched Ashkenazi Jews, and an age-matched control group from the Third National Health and Nutrition Examination Survey.Self-reported family history of longevity; prevalence of hypertension, diabetes mellitus, heart attacks, and strokes; and objective measurements of body mass index and fat mass.Parents of centenarians (born in approximately 1870) had a markedly greater ( approximately sevenfold) risk for longevity (reaching ages 90-99), supporting the notion that genetics contributed to longevity in these families. The offspring of long-lived parents had significantly lower prevalence of hypertension (by 23%), diabetes mellitus (by 50%), heart attacks (by 60%), and strokes (no events reported) than several age-matched control groups.Offspring of centenarians may inherit significantly better health. The authors suggest that a cohort of these subjects and their spouses is ideal to study the phenotype and genotype of longevity and its interaction with the environment." @default.
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- W1523160355 date "2004-01-22" @default.
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- W1523160355 title "Clinical Phenotype of Families with Longevity" @default.
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- W1523160355 doi "https://doi.org/10.1111/j.1532-5415.2004.52068.x" @default.
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