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- W1523487635 abstract "Abstract Cerium oxide nanoparticles have oxygen defects in their lattice structure that enable them to scavenge oxygen radicals. Recent reports have shown nanoceria to act a regenerative free radical scavenger in a physiological environment. The goal of our study was to perform a comprehensive analysis of the biological distribution and in vivo antioxidant capabilities of nanoceria. We examined three peroral (PO), intravenous (IV), and intraperitoneal (IP) administration routes along with deposition, clearance, histology and WBC counts in nanoceria administered mice. We also examined if nanoceria would decrease ROS production in mice treated with carbon tetrachloride (CCl4). As determined by inductively coupled plasma-mass spectrometry (ICP-MS), nanoceria organ deposition for IV and IP mice was greatest in the spleen followed by the liver, lungs, and kidneys. Elimination for all administration routes was through feces. Nanoceria distribution was confirmed with IVIS in vivo imaging, and deposition was confirmed with transmission electron microscopy (TEM). Nanoceria administration did not induce histopathology, however it did raise WBC counts. Nanoceria administration to mice with induced liver toxicity reduced liver 8-isoprostane, urine 8-OHdG, and plasma MDA levels markers of oxidative stress. Our studies show that nanoceria remains deposited in tissues and decreases ROS, suggesting that cerium oxide nanoparticles may be a useful antioxidant treatment for oxidative stress." @default.
- W1523487635 created "2016-06-24" @default.
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- W1523487635 date "2010-04-01" @default.
- W1523487635 modified "2023-09-23" @default.
- W1523487635 title "Bio-distribution and in vivo antioxidant properties of cerium oxide nanoparticles (87.26)" @default.
- W1523487635 doi "https://doi.org/10.4049/jimmunol.184.supp.87.26" @default.
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