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- W1523525412 abstract "Abstract The effects of exposure to nanoparticles of titanium dioxide (nano‐titanium) and cerium oxide (nano‐cerium) on gene expression and growth in Arabidopsis thaliana germinants were studied by using microarrays and quantitative real‐time polymerase chain reaction (qPCR), and by evaluating germinant phenotypic plasticity. Exposure to 12 d of either nano‐titania or nano‐ceria altered the regulation of 204 and 142 genes, respectively. Genes induced by the nanoparticles mainly include ontology groups annotated as stimuli responsive, including both abiotic (oxidative stress, salt stress, water transport) and biotic (respiratory burst as a defense against pathogens) stimuli. Further analysis of the differentially expressed genes indicates that both nanoparticles affected a range of metabolic processes (deoxyribonucleic acid [DNA] metabolism, hormone metabolism, tetrapyrrole synthesis, and photosynthesis). Individual exposures to the nanoparticles increased percentages of seeds with emergent radicles, early development of hypocotyls and cotyledons, and those with fully grown leaves. Although there were distinct differences between the nanoparticles in their affect on molecular mechanisms attributable to enhancing germinant growth, both particles altered similar suites of genes related to various pathways and processes related to enhanced growth. Environ Toxicol Chem 2015;34:70–83. Published 2014 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America." @default.
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- W1523525412 date "2014-11-03" @default.
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- W1523525412 title "Phenotypic and genomic responses to titanium dioxide and cerium oxide nanoparticles in<i>Arabidopsis</i>germinants" @default.
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- W1523525412 doi "https://doi.org/10.1002/etc.2756" @default.
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