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• W1523552557 abstract "Abstract Objectives: To summarise Antipsychotic Trials of Intervention Effectiveness with respect to clinical outcomes following the treatment of schizophrenia. Methods: Articles were searched from PubMed with key words Clinical Antipsychotic Trials of Intervention Effectiveness, and published from January 2000 to April 2008. Studies reporting original research findings concerning clinical outcomes from such trials in patients with schizophrenia were selected for review. Results: Conventional and atypical antipsychotics had similar clinical effectiveness, neurocognitive and functional outcomes. Among atypical antipsychotics, olanzapine showed better effectiveness but worse metabolic outcomes. Medical co-morbidity was common among schizophrenic patients. Conclusions: With reference to findings from Antipsychotic Trials of Intervention Effectiveness in schizophrenia, review of local prescribing and monitoring practice is recommended. Key words: Antipsychotic agents; Review; Schizophrenia Introduction The Antipsychotic Trials of Intervention Effectiveness (CATIE) in schizophrenia study was the largest project ever conducted to evaluate treatment effectiveness in real-world schizophrenic patients. The CATIE was supported by the National Institute of Mental Health and costed about US$50 million, lasted 4 years and involved over 50 clinical sites in the United States. About 1,500 patients participated in this 3-phase study. Articles concerning this study have been published since 2003 and many findings have been reported in the ensuing years. A variety of topics have been covered, some of which caused debate about the management of schizophrenia, especially with respect to clinical outcomes. The aim of this study was to review CATIE findings in the context of clinical outcomes for schizophrenia treatment. Methods Reports of original research findings from the CATIE study about patients with chronic schizophrenia are included in this review. To identify appropriate studies, a literature search was conducted using PubMed with key words Clinical Antipsychotic Trials of Intervention Effectiveness, and for articles published from January 2000 to April 2008. The search strategy yielded 124 English-language studies. The abstracts were obtained for further inspection. Eight studies were about the CATIE project for Alzheimer's disease, 9 used samples from the CATIE project for other research, 4 used CATIE assessment instruments for other research, 65 publications were editorials, reviews or correspondences about CATIE project, and 13 were unrelated. The remaining 25 studies met the inclusion criteria and were reviewed, and among them 18 dealt with clinical outcomes arising from interventions with antipsychotics. Results The studies selected for review deal with 4 outcome categories, namely clinical effectiveness, cognition, functionality, and metabolic status. Effectiveness and Cost-effectiveness According to a study by Lieberman et al,1 74% of the patients discontinued their study medication within 18 months. The time to discontinuation of treatment (for any reason) was significantly longer in those treated with olanzapine rather than quetiapine (p" @default.
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• W1523552557 date "2009-03-01" @default.
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• W1523552557 title "Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia: Selective Review on Clinical Outcomes" @default.
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