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- W152361454 abstract "The neurofibromatosis type 2 (NF2) tumor suppressor gene, NF2, is located on human chromosome 22 and was identified in 1993. Somatic genetic alterations of both copies of this gene are necessary for the development of schwannomas and most meningiomas, two common sporadic tumors of the central nervous system. Germ line mutations of one copy of NF2, with somatic mutation of the remaining allele, result in the inherited syndrome of the same name. Since cloning of NF2 over a decade ago, a vast amount of studies have been published describing the molecular genetics, molecular biology, and clinical features of NF2. There have been major advances in the understanding of the normal role of the NF2-encoded protein, its interaction with other cellular components, and its potential role in tumorigenesis. The data compiled to date have provided significant insight into the potential function of this protein in tumor suppression, but have also revealed the complexity of the cellular processes involved. In this article we summarize the most significant aspects of NF2 research over the past 3 decades." @default.
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- W152361454 date "2009-01-01" @default.
- W152361454 modified "2023-10-16" @default.
- W152361454 title "Neurofibromatosis Type 2: Further Questions and Answers" @default.
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- W152361454 doi "https://doi.org/10.1016/b978-008045046-9.00597-0" @default.
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