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- W1523617705 abstract "The mechanism of the antibody-potentiating action of complement was investigated. In the neutralization of herpes virus by immune serum, formation of virus-antibody complexes which are not necessarily neutral precedes viral inactivation. In the case of early immune serum containing complement-requiring neutralizing (CRN) antibody, the interval between virus-antibody binding and viral inactivation is very long, and the action of complement is to shorten this interval. The virus-CRN antibody binding, or sensitization of virus by CRN antibody, as well as the action of complement is quicker at 37° than at 4°. The virus-CRN antibody complex formed in the absence of complement is not easily dissociable by simple dilution, nor by other means such as sonic vibration; has no blocking effect against hyperimmune antibody; and remains sensitive to the antibody-potentiating action of complement during an early stage of adsorption to cells." @default.
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- W1523617705 date "1965-05-01" @default.
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- W1523617705 title "Studies on the neutralization of herpes simplex virus" @default.
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- W1523617705 doi "https://doi.org/10.1016/0042-6822(65)90026-7" @default.
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