Matches in SemOpenAlex for { <https://semopenalex.org/work/W1523643198> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1523643198 endingPage "82" @default.
- W1523643198 startingPage "74" @default.
- W1523643198 abstract "Abstract Rabbit muscle phosphofructokinase has been irradiated in solution with X-rays. The dose-response curve for the loss of catalytic activity was biphasic, indicating that the enzyme consists of two fractions of widely differing sensitivity to radiation. Sucrose gradient studies indicated that the resistant fraction was associated with high molecular weight aggregates of the enzyme. The sensitive fraction was found to be inactivated with a G value of 0.055. Measurements of the disappearance of SH groups upon irradiation and of the protective effect of p-chloromercuribenzoate blocking prior to irradiation indicated that destruction of SH groups plays an important role in the radiation-induced loss of the catalytic activity. The allosteric activity, as measured by the ability of AMP to reverse the ATP inhibition of the enzyme, was relatively resistant to radiation inactivation. Loss of allosteric activity did not occur until a considerable threshold dose had been accumulated. The shape of the dose-response curve could be explained by the radiation-induced changes in kinetic parameters. It was shown that the radiation-induced decrease in allosteric activity was due to a reduced sensitivity to ATP inhibition in the irradiated enzyme." @default.
- W1523643198 created "2016-06-24" @default.
- W1523643198 creator A5047336117 @default.
- W1523643198 creator A5081357167 @default.
- W1523643198 creator A5085579062 @default.
- W1523643198 date "1969-03-01" @default.
- W1523643198 modified "2023-09-27" @default.
- W1523643198 title "X-ray inactivation of phosphofructokinase" @default.
- W1523643198 cites W121598433 @default.
- W1523643198 cites W1269569823 @default.
- W1523643198 cites W1557691062 @default.
- W1523643198 cites W1587804137 @default.
- W1523643198 cites W1603868171 @default.
- W1523643198 cites W1775749144 @default.
- W1523643198 cites W1969770477 @default.
- W1523643198 cites W1996225323 @default.
- W1523643198 cites W2030478971 @default.
- W1523643198 cites W2067657396 @default.
- W1523643198 cites W2074086897 @default.
- W1523643198 cites W2084264620 @default.
- W1523643198 cites W2084563998 @default.
- W1523643198 cites W2135512849 @default.
- W1523643198 cites W2138557102 @default.
- W1523643198 cites W4245346083 @default.
- W1523643198 cites W95753805 @default.
- W1523643198 doi "https://doi.org/10.1016/0005-2744(69)90133-8" @default.
- W1523643198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4237610" @default.
- W1523643198 hasPublicationYear "1969" @default.
- W1523643198 type Work @default.
- W1523643198 sameAs 1523643198 @default.
- W1523643198 citedByCount "11" @default.
- W1523643198 crossrefType "journal-article" @default.
- W1523643198 hasAuthorship W1523643198A5047336117 @default.
- W1523643198 hasAuthorship W1523643198A5081357167 @default.
- W1523643198 hasAuthorship W1523643198A5085579062 @default.
- W1523643198 hasConcept C122245378 @default.
- W1523643198 hasConcept C181199279 @default.
- W1523643198 hasConcept C185592680 @default.
- W1523643198 hasConcept C20251656 @default.
- W1523643198 hasConcept C55493867 @default.
- W1523643198 hasConceptScore W1523643198C122245378 @default.
- W1523643198 hasConceptScore W1523643198C181199279 @default.
- W1523643198 hasConceptScore W1523643198C185592680 @default.
- W1523643198 hasConceptScore W1523643198C20251656 @default.
- W1523643198 hasConceptScore W1523643198C55493867 @default.
- W1523643198 hasIssue "1" @default.
- W1523643198 hasLocation W15236431981 @default.
- W1523643198 hasLocation W15236431982 @default.
- W1523643198 hasOpenAccess W1523643198 @default.
- W1523643198 hasPrimaryLocation W15236431981 @default.
- W1523643198 hasRelatedWork W1531601525 @default.
- W1523643198 hasRelatedWork W1990781990 @default.
- W1523643198 hasRelatedWork W2314643286 @default.
- W1523643198 hasRelatedWork W2606768298 @default.
- W1523643198 hasRelatedWork W2606769243 @default.
- W1523643198 hasRelatedWork W2606837276 @default.
- W1523643198 hasRelatedWork W2748952813 @default.
- W1523643198 hasRelatedWork W2899084033 @default.
- W1523643198 hasRelatedWork W2948807893 @default.
- W1523643198 hasRelatedWork W2778153218 @default.
- W1523643198 hasVolume "178" @default.
- W1523643198 isParatext "false" @default.
- W1523643198 isRetracted "false" @default.
- W1523643198 magId "1523643198" @default.
- W1523643198 workType "article" @default.