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- W1523644536 abstract "Autism is a developmental disorder involving early brain overgrowth. Overgrowth and dysfunction are strongly evident at young ages in prefrontal and temporal cortices. The authors use computerized stereology to examine the neural basis of early brain overgrowth in autism. They indicate that autism does involve a substantial overabundance of prefrontal neurons, and the greater the excess, the greater the overall deviant brain size. This chapter presents a study conducted on brains from n = 9 autistic and n = 7 control males, aged 2 to 16 years. Two major prefrontal divisions are analyzed: dorsolateral (DL-PFC) and mesial (M-PFC) prefrontal cortex. The findings point to a second critical neuropathological phenomenon in autism: excess neuron numbers in the brains of young males with autism appear to be removed across decades, unlike the normal brain in which naturally occurring apoptosis removes excess rapidly across just a few months of prenatal and perinatal life." @default.
- W1523644536 created "2016-06-24" @default.
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- W1523644536 date "2013-11-22" @default.
- W1523644536 modified "2023-09-23" @default.
- W1523644536 title "An Overabundance of Prefrontal Cortex Neurons Underlies Early Brain Overgrowth in Autism" @default.
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- W1523644536 doi "https://doi.org/10.1002/9781118444177.ch6" @default.
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