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• W1523693453 startingPage "1" @default.
• W1523693453 abstract "Abstract Drug‐metabolizing enzymes (DMEs) are primarily expressed in the liver but their role in the extrahepatic tissues such as gastrointestinal tract (GIT), pulmonary, excretory, nervous, cardiovascular system, and skin cannot be neglected. Generally, the expression of DMEs in extrahepatic tissues is quantitatively lower than that in the liver, but there are a few enzymes such as CYP1A1, CYP1B1, CYP2F1, and CYP2U1 that are more abundant in extrahepatic organs. As many extrahepatic organs are portals for administered drugs, DMEs expressed in these organs can be responsible for significant metabolism, leading to first‐pass effects and lower bioavailability. Extrahepatic DMEs are also involved in bioactivation of prodrugs and formation of reactive metabolites that may interact with cellular components, resulting in organ‐specific toxicity. Activity and expression of extrahepatic DMEs is often altered by coadministered drugs, leading to drug–drug interactions. Expression of DMEs in living beings affected by a host of environmental and genetic factors such as genetic polymorphism, age, gender, pathophysiological conditions, inborn errors in metabolism, food habits, and environmental pollutants, contributing to varied drug effects and idiosyncratic toxicities." @default.
• W1523693453 created "2016-06-24" @default.
• W1523693453 creator A5024981431 @default.
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• W1523693453 creator A5084405945 @default.
• W1523693453 creator A5085708287 @default.
• W1523693453 creator A5089653592 @default.
• W1523693453 date "2012-10-15" @default.
• W1523693453 modified "2023-10-12" @default.
• W1523693453 title "Extrahepatic Drug-Metabolizing Enzymes and Their Significance" @default.
• W1523693453 cites W124097478 @default.
• W1523693453 cites W143355275 @default.
• W1523693453 cites W1482946335 @default.
• W1523693453 cites W1508531867 @default.
• W1523693453 cites W1509336239 @default.
• W1523693453 cites W1518370339 @default.
• W1523693453 cites W1522010415 @default.
• W1523693453 cites W1541432106 @default.
• W1523693453 cites W1559928164 @default.
• W1523693453 cites W1584188206 @default.
• W1523693453 cites W1592099189 @default.
• W1523693453 cites W1597705966 @default.
• W1523693453 cites W1600350812 @default.
• W1523693453 cites W160491367 @default.
• W1523693453 cites W1605785874 @default.
• W1523693453 cites W175009260 @default.
• W1523693453 cites W183418307 @default.
• W1523693453 cites W1849763436 @default.
• W1523693453 cites W1876850929 @default.
• W1523693453 cites W1913730804 @default.
• W1523693453 cites W1922138182 @default.
• W1523693453 cites W1923205770 @default.
• W1523693453 cites W1958513894 @default.
• W1523693453 cites W1963543020 @default.
• W1523693453 cites W1963889605 @default.
• W1523693453 cites W1964263053 @default.
• W1523693453 cites W1964467281 @default.
• W1523693453 cites W1964552738 @default.
• W1523693453 cites W1964628055 @default.
• W1523693453 cites W1964721034 @default.
• W1523693453 cites W1965199991 @default.
• W1523693453 cites W1965239974 @default.
• W1523693453 cites W1966132884 @default.
• W1523693453 cites W1966142961 @default.
• W1523693453 cites W1966184290 @default.
• W1523693453 cites W1966617583 @default.
• W1523693453 cites W1966882458 @default.
• W1523693453 cites W1967978735 @default.
• W1523693453 cites W1968508121 @default.
• W1523693453 cites W1969592782 @default.
• W1523693453 cites W1969747613 @default.
• W1523693453 cites W1970086066 @default.
• W1523693453 cites W1970168533 @default.
• W1523693453 cites W1971802956 @default.
• W1523693453 cites W1972020040 @default.
• W1523693453 cites W1972387387 @default.
• W1523693453 cites W1972499668 @default.
• W1523693453 cites W1972529527 @default.
• W1523693453 cites W1972857511 @default.
• W1523693453 cites W1973619289 @default.
• W1523693453 cites W1974621673 @default.
• W1523693453 cites W1975065437 @default.
• W1523693453 cites W1976622515 @default.
• W1523693453 cites W1977443399 @default.
• W1523693453 cites W1977951934 @default.
• W1523693453 cites W1978234601 @default.
• W1523693453 cites W1978921548 @default.
• W1523693453 cites W1978976783 @default.
• W1523693453 cites W1979243197 @default.
• W1523693453 cites W1979732900 @default.
• W1523693453 cites W1980094999 @default.
• W1523693453 cites W1980612293 @default.
• W1523693453 cites W1980766303 @default.
• W1523693453 cites W1981394260 @default.
• W1523693453 cites W1982633116 @default.
• W1523693453 cites W1982806204 @default.
• W1523693453 cites W1982842654 @default.
• W1523693453 cites W1983367741 @default.
• W1523693453 cites W1983599922 @default.
• W1523693453 cites W1983818310 @default.
• W1523693453 cites W1984170088 @default.
• W1523693453 cites W1984263177 @default.
• W1523693453 cites W1985232100 @default.
• W1523693453 cites W1985696642 @default.
• W1523693453 cites W1985976452 @default.
• W1523693453 cites W1985981833 @default.
• W1523693453 cites W1986052966 @default.
• W1523693453 cites W1986254345 @default.
• W1523693453 cites W1986338215 @default.
• W1523693453 cites W1986342669 @default.
• W1523693453 cites W1986475553 @default.
• W1523693453 cites W1986486025 @default.
• W1523693453 cites W1986652646 @default.
• W1523693453 cites W1987915913 @default.
• W1523693453 cites W1988070767 @default.
• W1523693453 cites W1988121024 @default.

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