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- W1523737655 abstract "Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS.…" @default.
- W1523737655 created "2016-06-24" @default.
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- W1523737655 creator A5028232421 @default.
- W1523737655 creator A5044671434 @default.
- W1523737655 creator A5076889483 @default.
- W1523737655 date "2012-05-14" @default.
- W1523737655 modified "2023-10-10" @default.
- W1523737655 title "Intestinal barrier function in health and gastrointestinal disease" @default.
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- W1523737655 doi "https://doi.org/10.1111/j.1365-2982.2012.01921.x" @default.
- W1523737655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5595063" @default.
- W1523737655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22583600" @default.
- W1523737655 hasPublicationYear "2012" @default.
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