FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1523767501> ?p ?o ?g. }

• W1523767501 endingPage "10" @default.
• W1523767501 startingPage "1" @default.
• W1523767501 abstract "As organisms age, a considerable decrease in protein synthesis takes place in all tissues. Among the possible causes of the decline of translation in old animals are the modifications of elongation factor-2 (eEF-2). eEF-2 occupies an essential role in protein synthesis where it catalyzes the ribosomal translocation reaction. eEF-2 is particularly sensitive to increased oxidative stress. However, all oxidants do not affect eEF-2, only compounds that increase lipid peroxidation. As peroxides are unstable compounds, they decompose and generate a series of highly reactive compounds, including aldehydes malondialdehyde (MDA) and 4-hydroxynoenal (HNE). We have previously reported that hepatic eEF-2 forms adducts with low-molecular weight aldehydes, MDA and HNE. Therefore, the protection of eEF-2 must be specifically carried out by a compound with lipoperoxyl radical-scavenging features such as melatonin. In this article, we show the ability of melatonin to protect against the changes that occur in the eEF-2 under conditions of lipid peroxidation induced by cumene hydroperoxide (CH), a compound used experimentally to induce lipid breakdown. As experimental models, we used cultured cells and rats treated with this oxidant compound. eEF-2 levels, adduct formation of this protein with MDA and HNE, and lipid peroxides were determined. In the cultured cells, protein synthesis rate was also measured. Our results show that melatonin prevented the molecular changes in eEF-2 and the decline in protein synthesis rate secondary to lipid peroxidation. The results also show that serum levels of several hormones were affected by CH-induced oxidative stress, which was partially or totally prevented by melatonin." @default.
• W1523767501 created "2016-06-24" @default.
• W1523767501 creator A5015315342 @default.
• W1523767501 creator A5036077377 @default.
• W1523767501 creator A5044864756 @default.
• W1523767501 creator A5061421555 @default.
• W1523767501 creator A5081908980 @default.
• W1523767501 date "2012-03-29" @default.
• W1523767501 modified "2023-10-03" @default.
• W1523767501 title "In vitro and in vivo protection by melatonin against the decline of elongation factor-2 caused by lipid peroxidation: preservation of protein synthesis" @default.
• W1523767501 cites W1485256456 @default.
• W1523767501 cites W1576346700 @default.
• W1523767501 cites W1607630441 @default.
• W1523767501 cites W1731932233 @default.
• W1523767501 cites W1964130521 @default.
• W1523767501 cites W1969809278 @default.
• W1523767501 cites W1971004115 @default.
• W1523767501 cites W1972259716 @default.
• W1523767501 cites W1976777914 @default.
• W1523767501 cites W1977285013 @default.
• W1523767501 cites W1978611087 @default.
• W1523767501 cites W1995899406 @default.
• W1523767501 cites W1996710793 @default.
• W1523767501 cites W2008020214 @default.
• W1523767501 cites W2008657411 @default.
• W1523767501 cites W2015216354 @default.
• W1523767501 cites W2016860528 @default.
• W1523767501 cites W2019453794 @default.
• W1523767501 cites W2042951732 @default.
• W1523767501 cites W2049453065 @default.
• W1523767501 cites W2050585388 @default.
• W1523767501 cites W2051651703 @default.
• W1523767501 cites W2052143287 @default.
• W1523767501 cites W2054241048 @default.
• W1523767501 cites W2057522312 @default.
• W1523767501 cites W2060605462 @default.
• W1523767501 cites W2064500139 @default.
• W1523767501 cites W2075038429 @default.
• W1523767501 cites W2075678912 @default.
• W1523767501 cites W2076540828 @default.
• W1523767501 cites W2077805320 @default.
• W1523767501 cites W2078420174 @default.
• W1523767501 cites W2078843599 @default.
• W1523767501 cites W2080326524 @default.
• W1523767501 cites W2085651394 @default.
• W1523767501 cites W2091558798 @default.
• W1523767501 cites W2094423266 @default.
• W1523767501 cites W2098619885 @default.
• W1523767501 cites W2101861123 @default.
• W1523767501 cites W2125475249 @default.
• W1523767501 cites W2126214612 @default.
• W1523767501 cites W2129434699 @default.
• W1523767501 cites W2130924839 @default.
• W1523767501 cites W2138643199 @default.
• W1523767501 cites W2142684840 @default.
• W1523767501 cites W2144658476 @default.
• W1523767501 cites W2147597448 @default.
• W1523767501 cites W2165348489 @default.
• W1523767501 cites W2316319776 @default.
• W1523767501 cites W4320578141 @default.
• W1523767501 doi "https://doi.org/10.1111/j.1600-079x.2011.00961.x" @default.
• W1523767501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22462727" @default.
• W1523767501 hasPublicationYear "2012" @default.
• W1523767501 type Work @default.
• W1523767501 sameAs 1523767501 @default.
• W1523767501 citedByCount "10" @default.
• W1523767501 countsByYear W15237675012013 @default.
• W1523767501 countsByYear W15237675012014 @default.
• W1523767501 countsByYear W15237675012016 @default.
• W1523767501 countsByYear W15237675012017 @default.
• W1523767501 countsByYear W15237675012020 @default.
• W1523767501 countsByYear W15237675012021 @default.
• W1523767501 countsByYear W15237675012022 @default.
• W1523767501 crossrefType "journal-article" @default.
• W1523767501 hasAuthorship W1523767501A5015315342 @default.
• W1523767501 hasAuthorship W1523767501A5036077377 @default.
• W1523767501 hasAuthorship W1523767501A5044864756 @default.
• W1523767501 hasAuthorship W1523767501A5061421555 @default.
• W1523767501 hasAuthorship W1523767501A5081908980 @default.
• W1523767501 hasConcept C104317684 @default.
• W1523767501 hasConcept C134018914 @default.
• W1523767501 hasConcept C139124968 @default.
• W1523767501 hasConcept C185592680 @default.
• W1523767501 hasConcept C2776151105 @default.
• W1523767501 hasConcept C2778182776 @default.
• W1523767501 hasConcept C2778401633 @default.
• W1523767501 hasConcept C2780829032 @default.
• W1523767501 hasConcept C55493867 @default.
• W1523767501 hasConcept C57600042 @default.
• W1523767501 hasConcept C67705224 @default.
• W1523767501 hasConcept C86803240 @default.
• W1523767501 hasConcept C88478588 @default.
• W1523767501 hasConceptScore W1523767501C104317684 @default.
• W1523767501 hasConceptScore W1523767501C134018914 @default.
• W1523767501 hasConceptScore W1523767501C139124968 @default.
• W1523767501 hasConceptScore W1523767501C185592680 @default.
• W1523767501 hasConceptScore W1523767501C2776151105 @default.
• W1523767501 hasConceptScore W1523767501C2778182776 @default.

• next