FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1523788432> ?p ?o ?g. }

• W1523788432 endingPage "6283" @default.
• W1523788432 startingPage "6273" @default.
• W1523788432 abstract "The immunomodulatory effects of vitamin D have been described following chronic oral administration to mice or supplementation of cell cultures with 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D. In this study, topically applied 1,25(OH)(2)D(3), enhanced the suppressive capacity of CD4(+)CD25(+) cells from the draining lymph nodes. The effects of topical 1,25(OH)(2)D(3) were compared with those of UVB irradiation, which is the environmental factor required for 1,25(OH)(2)D(3) production in skin. CD4(+) cells from the skin-draining lymph nodes (SDLN) of either 1,25(OH)(2)D(3)-treated or UVB-irradiated mice had reduced capacity to proliferate to Ags presented in vitro, and could suppress Ag-specific immune responses upon adoptive transfer into naive mice. This regulation was lost upon removal of CD4(+)CD25(+) cells. Furthermore, purified CD4(+)CD25(+) cells from the SDLN of 1,25(OH)(2)D(3)-treated or UVB-irradiated mice compared with equal numbers of CD4(+)CD25(+) cells from control mice had increased capacity to suppress immune responses in both in vitro and in vivo assay systems. Following the sensitization of recipient mice with OVA, the proportion of CD4(+)Foxp3(+) cells of donor origin significantly increased in recipients of CD4(+)CD25(+) cells from the SDLN of 1,25(OH)(2)D(3)-treated mice, indicating that these regulatory T cells can expand in vivo with antigenic stimulation. These studies suggest that 1,25(OH)(2)D(3) may be an important mediator by which UVB-irradiation exerts some of its immunomodulatory effects." @default.
• W1523788432 created "2016-06-24" @default.
• W1523788432 creator A5001962218 @default.
• W1523788432 creator A5008823731 @default.
• W1523788432 creator A5013853681 @default.
• W1523788432 creator A5018181375 @default.
• W1523788432 creator A5022756755 @default.
• W1523788432 creator A5058298310 @default.
• W1523788432 creator A5064627053 @default.
• W1523788432 creator A5081099768 @default.
• W1523788432 date "2007-11-01" @default.
• W1523788432 modified "2023-09-28" @default.
• W1523788432 title "Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes" @default.
• W1523788432 cites W1598062630 @default.
• W1523788432 cites W1947738344 @default.
• W1523788432 cites W1975367344 @default.
• W1523788432 cites W1977131610 @default.
• W1523788432 cites W1984638038 @default.
• W1523788432 cites W2000609001 @default.
• W1523788432 cites W2003158223 @default.
• W1523788432 cites W2007223760 @default.
• W1523788432 cites W2008870899 @default.
• W1523788432 cites W2017723155 @default.
• W1523788432 cites W2026951206 @default.
• W1523788432 cites W2029728577 @default.
• W1523788432 cites W2034024838 @default.
• W1523788432 cites W2034197398 @default.
• W1523788432 cites W2039390906 @default.
• W1523788432 cites W2039709829 @default.
• W1523788432 cites W2040619287 @default.
• W1523788432 cites W2056139144 @default.
• W1523788432 cites W2064990965 @default.
• W1523788432 cites W2066298347 @default.
• W1523788432 cites W2082775445 @default.
• W1523788432 cites W2100895591 @default.
• W1523788432 cites W2101781154 @default.
• W1523788432 cites W2106044877 @default.
• W1523788432 cites W2108825111 @default.
• W1523788432 cites W2115710851 @default.
• W1523788432 cites W2116151144 @default.
• W1523788432 cites W2127755180 @default.
• W1523788432 cites W2134002548 @default.
• W1523788432 cites W2138413317 @default.
• W1523788432 cites W2140735585 @default.
• W1523788432 cites W2153716166 @default.
• W1523788432 cites W2153911324 @default.
• W1523788432 cites W2161882037 @default.
• W1523788432 cites W2170384111 @default.
• W1523788432 cites W2316348212 @default.
• W1523788432 doi "https://doi.org/10.4049/jimmunol.179.9.6273" @default.
• W1523788432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17947703" @default.
• W1523788432 hasPublicationYear "2007" @default.
• W1523788432 type Work @default.
• W1523788432 sameAs 1523788432 @default.
• W1523788432 citedByCount "247" @default.
• W1523788432 countsByYear W15237884322012 @default.
• W1523788432 countsByYear W15237884322013 @default.
• W1523788432 countsByYear W15237884322014 @default.
• W1523788432 countsByYear W15237884322015 @default.
• W1523788432 countsByYear W15237884322016 @default.
• W1523788432 countsByYear W15237884322017 @default.
• W1523788432 countsByYear W15237884322018 @default.
• W1523788432 countsByYear W15237884322019 @default.
• W1523788432 countsByYear W15237884322020 @default.
• W1523788432 countsByYear W15237884322021 @default.
• W1523788432 countsByYear W15237884322022 @default.
• W1523788432 countsByYear W15237884322023 @default.
• W1523788432 crossrefType "journal-article" @default.
• W1523788432 hasAuthorship W1523788432A5001962218 @default.
• W1523788432 hasAuthorship W1523788432A5008823731 @default.
• W1523788432 hasAuthorship W1523788432A5013853681 @default.
• W1523788432 hasAuthorship W1523788432A5018181375 @default.
• W1523788432 hasAuthorship W1523788432A5022756755 @default.
• W1523788432 hasAuthorship W1523788432A5058298310 @default.
• W1523788432 hasAuthorship W1523788432A5064627053 @default.
• W1523788432 hasAuthorship W1523788432A5081099768 @default.
• W1523788432 hasBestOaLocation W15237884321 @default.
• W1523788432 hasConcept C124490489 @default.
• W1523788432 hasConcept C126322002 @default.
• W1523788432 hasConcept C134018914 @default.
• W1523788432 hasConcept C142724271 @default.
• W1523788432 hasConcept C150903083 @default.
• W1523788432 hasConcept C153911025 @default.
• W1523788432 hasConcept C185592680 @default.
• W1523788432 hasConcept C202751555 @default.
• W1523788432 hasConcept C203014093 @default.
• W1523788432 hasConcept C207001950 @default.
• W1523788432 hasConcept C24998067 @default.
• W1523788432 hasConcept C2776090121 @default.
• W1523788432 hasConcept C2779720271 @default.
• W1523788432 hasConcept C2779727006 @default.
• W1523788432 hasConcept C55493867 @default.
• W1523788432 hasConcept C71924100 @default.
• W1523788432 hasConcept C79484868 @default.
• W1523788432 hasConcept C86803240 @default.
• W1523788432 hasConcept C8891405 @default.
• W1523788432 hasConcept C90375314 @default.
• W1523788432 hasConcept C98274493 @default.

• next