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- W1523906243 abstract "Abstract The antibody response, interferon synthesis, viremia and replication of virus in the lungs of mice following aerogenic immunization with mengovirus-37A were studied. Virus titers in blood and lungs were maximal at day 1, whereas interferon activity was greatest at day 7 after aerosol exposure. Hemagglutination-inhibition (HAI) activity (2-ME sensitive) was detected on day 6, neutralizing antibodies by day 9 (also 2-ME sensitive) and complement fixation tests were positive on day 12. After day 12, 2-ME resistant HAI and neutralizing antibodies were observed. Maximum HAI and neutralizing antibody titers occurred on day 31. The usual pattern of early 19 S response followed by 7 S antibody formation was observed following aerogenic immunization of mice with mengo virus-37A. However, the time required for antibody to appear was longer than that noted in other immunization studies using other routes of vaccination." @default.
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- W1523906243 date "1969-07-01" @default.
- W1523906243 modified "2023-10-17" @default.
- W1523906243 title "The Immunologic Response of the Mouse to Aerosols of an Attenuated Encephalomyocarditis Virus Strain" @default.
- W1523906243 doi "https://doi.org/10.4049/jimmunol.103.1.79" @default.
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