FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1523986905> ?p ?o ?g. }

• W1523986905 endingPage "357" @default.
• W1523986905 startingPage "351" @default.
• W1523986905 abstract "Dodecanedioic acid (C12) is an even-numbered dicarboxylic acid (DA). Dicarboxylic acids are water-soluble substances with a metabolic pathway intermediate to those of lipids and carbohydrates. Previous studies showed that contrary to other DAs, very low amounts of C12 are lost with urine. The effects of 46.6 mmol of C12 intravenous infusion for 195 min on blood glucose levels were investigated in five patients with non‐insulin-dependent diabetes mellitus (NIDDM), with a good metabolic compensation, and in five healthy volunteers matched for gender, age, and body mass index. Blood samples were taken every 15 min for a period of 360 min to measure glucose, insulin, C-peptide, ketone bodies, and free fatty acid (FFA) levels, and 24-h urine samples were collected to measure C12 and urea excretion. Plasma and urinary C12 concentrations were determined by high-pressure liquid chromatography (HPLC). Indirect calorimetry was continuously performed both basally and during the study period. The average 24-h urinary excretion of C12 was 6.5% versus 6.7% of the administered dose, respectively, in NIDDM patients and in healthy controls. The area under the curve (AUC) values of plasma C12 were 279.9 6 42.7 mmol in NIDDM patients and 219.7 6 14.0 mmol in controls (P 5 ns). Plasma glucose levels significantly decreased in NIDDM patients during C12 infusion (from 7.86 0.6 to 5.460.8 mM at the end of the study period, P , 0.05). Lactate plasma concentration decreased in NIDDM patients from 3.5 6 0.2 to 1.5 6 0.1 mM (P , 0.001), whereas blood pyruvate increased at the end of the experimental session from 26.0 6 11.6 to 99.5 6 14.9 m M( P , 0.01). Free fatty acids decreased in diabetic patients from the beginning until the end of C12 infusion, although this difference did not reach statistical significance. No significant increase was found between basal and final values in V ˙O 2 consumption and in the values of nonprotein respiratory quotient in both groups of subjects examined. The experimental data indicate that C12 infusion decreases plasma glucose levels in NIDDM patients to normal range without influencing plasma insulin levels. The balance between pyruvate and lactate was affected by C12 infusion only in diabetics patients. C12 might represent a fuel substrate immediately available for tissue energy requirements, especially in conditions such as diabetes mellitus in which glucose metabolism is impaired. Nutrition 1998; 14:351‐357. ©Elsevier Science Inc. 1998" @default.
• W1523986905 created "2016-06-24" @default.
• W1523986905 creator A5002391359 @default.
• W1523986905 creator A5013357762 @default.
• W1523986905 creator A5032296033 @default.
• W1523986905 creator A5053488036 @default.
• W1523986905 creator A5070853807 @default.
• W1523986905 creator A5073460543 @default.
• W1523986905 date "1998-01-01" @default.
• W1523986905 modified "2023-10-04" @default.
• W1523986905 title "The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients" @default.
• W1523986905 cites W1507062230 @default.
• W1523986905 cites W1507710640 @default.
• W1523986905 cites W1547646031 @default.
• W1523986905 cites W1566671638 @default.
• W1523986905 cites W1741635409 @default.
• W1523986905 cites W1967791869 @default.
• W1523986905 cites W1976050174 @default.
• W1523986905 cites W1977472510 @default.
• W1523986905 cites W1982563030 @default.
• W1523986905 cites W1990729981 @default.
• W1523986905 cites W1993167406 @default.
• W1523986905 cites W1993480864 @default.
• W1523986905 cites W2006383815 @default.
• W1523986905 cites W2010181251 @default.
• W1523986905 cites W2023189012 @default.
• W1523986905 cites W2031965656 @default.
• W1523986905 cites W2033733866 @default.
• W1523986905 cites W2040143579 @default.
• W1523986905 cites W2040667966 @default.
• W1523986905 cites W2042363723 @default.
• W1523986905 cites W2092604675 @default.
• W1523986905 cites W2108887720 @default.
• W1523986905 cites W2128749506 @default.
• W1523986905 cites W2130200187 @default.
• W1523986905 cites W2343952589 @default.
• W1523986905 cites W62898540 @default.
• W1523986905 hasPublicationYear "1998" @default.
• W1523986905 type Work @default.
• W1523986905 sameAs 1523986905 @default.
• W1523986905 citedByCount "0" @default.
• W1523986905 crossrefType "journal-article" @default.
• W1523986905 hasAuthorship W1523986905A5002391359 @default.
• W1523986905 hasAuthorship W1523986905A5013357762 @default.
• W1523986905 hasAuthorship W1523986905A5032296033 @default.
• W1523986905 hasAuthorship W1523986905A5053488036 @default.
• W1523986905 hasAuthorship W1523986905A5070853807 @default.
• W1523986905 hasAuthorship W1523986905A5073460543 @default.
• W1523986905 hasConcept C10146269 @default.
• W1523986905 hasConcept C126322002 @default.
• W1523986905 hasConcept C134018914 @default.
• W1523986905 hasConcept C179998833 @default.
• W1523986905 hasConcept C185592680 @default.
• W1523986905 hasConcept C2775920511 @default.
• W1523986905 hasConcept C2779306644 @default.
• W1523986905 hasConcept C2780026642 @default.
• W1523986905 hasConcept C2780365088 @default.
• W1523986905 hasConcept C31532488 @default.
• W1523986905 hasConcept C43617362 @default.
• W1523986905 hasConcept C523546767 @default.
• W1523986905 hasConcept C54355233 @default.
• W1523986905 hasConcept C55493867 @default.
• W1523986905 hasConcept C555293320 @default.
• W1523986905 hasConcept C62231903 @default.
• W1523986905 hasConcept C71924100 @default.
• W1523986905 hasConcept C77411442 @default.
• W1523986905 hasConcept C86803240 @default.
• W1523986905 hasConceptScore W1523986905C10146269 @default.
• W1523986905 hasConceptScore W1523986905C126322002 @default.
• W1523986905 hasConceptScore W1523986905C134018914 @default.
• W1523986905 hasConceptScore W1523986905C179998833 @default.
• W1523986905 hasConceptScore W1523986905C185592680 @default.
• W1523986905 hasConceptScore W1523986905C2775920511 @default.
• W1523986905 hasConceptScore W1523986905C2779306644 @default.
• W1523986905 hasConceptScore W1523986905C2780026642 @default.
• W1523986905 hasConceptScore W1523986905C2780365088 @default.
• W1523986905 hasConceptScore W1523986905C31532488 @default.
• W1523986905 hasConceptScore W1523986905C43617362 @default.
• W1523986905 hasConceptScore W1523986905C523546767 @default.
• W1523986905 hasConceptScore W1523986905C54355233 @default.
• W1523986905 hasConceptScore W1523986905C55493867 @default.
• W1523986905 hasConceptScore W1523986905C555293320 @default.
• W1523986905 hasConceptScore W1523986905C62231903 @default.
• W1523986905 hasConceptScore W1523986905C71924100 @default.
• W1523986905 hasConceptScore W1523986905C77411442 @default.
• W1523986905 hasConceptScore W1523986905C86803240 @default.
• W1523986905 hasIssue "4" @default.
• W1523986905 hasLocation W15239869051 @default.
• W1523986905 hasOpenAccess W1523986905 @default.
• W1523986905 hasPrimaryLocation W15239869051 @default.
• W1523986905 hasRelatedWork W1965213326 @default.
• W1523986905 hasRelatedWork W1994323704 @default.
• W1523986905 hasRelatedWork W2003439600 @default.
• W1523986905 hasRelatedWork W2039337935 @default.
• W1523986905 hasRelatedWork W2039986911 @default.
• W1523986905 hasRelatedWork W2049459543 @default.
• W1523986905 hasRelatedWork W2059794695 @default.
• W1523986905 hasRelatedWork W2075173301 @default.

• next