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- W1524026612 abstract "Using a very sensitive double antibody electrophoretic technique, we have found alpha-1 fetoprotein (AFP) to occur transiently in the serum of adults during the course of acute viral hepatitis associated with Australia antigen (Au(1)) but not with acute viral hepatitis unassociated with Au(1). Occurrence in adult serum of this protein, which is a normal embryonic serum alpha-1 globulin, has heretofore been associated with the presence of either primary hepatic malignancy or certain germinal cell cancers of the testis and ovary. The possible significance of the reappearance of AFP relative to cellular retro-differentiation in viral hepatitis and hepatic malignancy is discussed. En utilisant une technique électrophorétique double très sensible, nous avons constaté que l'alpha-1 fœtoprotéine (AFP) apparaǐt passagèrement dans le sérum des adultes au cours d'une hépatite virale aiguë, mais seulement si cette hépatite est associée à l'antigène Australia (Au(1)). L'apparition dans le sérum des adultes de cette protéine, qui est une globuline alpha-1 normale du sérum embryonnaire, a jusqu'ici été associée à la présence d'une affection maligne primitive du foie ou à certains cancers des cellules germinates des testicules et des ovaires. Les auteurs analysent la signification possible de la réapparition de l'AFP sous l'angle de la rétro-différenciation cellulaire dans l'hèpatite virale et l'affection hépatique maligne." @default.
- W1524026612 created "2016-06-24" @default.
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- W1524026612 date "1971-11-15" @default.
- W1524026612 modified "2023-09-25" @default.
- W1524026612 title "Occurrence of alpha-fetoprotein in acute viral hepatitis" @default.
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- W1524026612 doi "https://doi.org/10.1002/ijc.2910080309" @default.
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