FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1524203595> ?p ?o ?g. }

• W1524203595 abstract "Background Non‐specific cough is defined as non‐productive cough in the absence of identifiable respiratory disease or known aetiology. It is commonly seen in paediatric practice. These children are treated with a variety of therapies including anti‐histamines. Also, anti‐histamines are advocated as an empirical treatment in adults with chronic cough. Objectives To evaluate the effectiveness of anti‐histamines in treating children with prolonged non‐specific cough. Search methods We searched the Cochrane Register of Controlled Trials (CENTRAL), MEDLINE, OLDMEDLINE and EMBASE databases. The latest searches were performed in November 2009. Selection criteria All randomised controlled trials comparing anti‐histamines with a placebo or placebo‐like medication with cough as an outcome, where cough is not primarily related to an underlying respiratory disorder such as cystic fibrosis, asthma, or suppurative lung disease. Data collection and analysis Two review authors independently assessed study quality and extracted data. Main results Three included therapeutic studies had 182 randomised participants with 162 completing the trials although in one study, children with recurrent wheeze were also included. The four included safety evaluation studies randomised 3166 participants with 2862 completing the trials. Clinical heterogeneity was evident and limited data prevented combining data for meta‐analysis. The two larger therapeutic studies described significant improvement in both the intervention and the placebo/placebo‐like arms with no significant difference between the two groups. In the study with the smallest sample size, cetirizine (a second generation anti‐histamine) was significantly more efficacious than placebo in reducing chronic cough in children associated with seasonal allergic rhinitis, and the effect was seen within two weeks of therapy. In contrast three of the larger evaluation studies that enrolled children with allergic rhinitis described a non‐significant increase in cough as an adverse event. Combined data from the four safety evaluation studies revealed a non‐significant difference between groups (OR 1.47 , 95% CI 0.86, 2.49) for cough as an adverse event but the trend favoured the placebo arm. Authors' conclusions This review has significant limitations. However, our finding of uncertain efficacy of anti‐histamines for chronic cough are similar to that for acute cough in children. In contrast to recommendations in adults with chronic cough, anti‐histamines cannot be recommended as empirical therapy for children with chronic cough. If anti‐histamines were to be trialled in these children, current data suggest a clinical response (time to response) occurs within two weeks of therapy. However the use of anti‐histamines in children with non‐specific cough has to be balanced against the well known risk of adverse events especially in very young children." @default.
• W1524203595 created "2016-06-24" @default.
• W1524203595 creator A5015755650 @default.
• W1524203595 creator A5024087517 @default.
• W1524203595 creator A5060883082 @default.
• W1524203595 date "2008-04-23" @default.
• W1524203595 modified "2023-10-17" @default.
• W1524203595 title "Anti-histamines for prolonged non-specific cough in children" @default.
• W1524203595 cites W1496717739 @default.
• W1524203595 cites W1854890399 @default.
• W1524203595 cites W1935276935 @default.
• W1524203595 cites W1969734467 @default.
• W1524203595 cites W1975612231 @default.
• W1524203595 cites W1976141231 @default.
• W1524203595 cites W1979149137 @default.
• W1524203595 cites W1980939736 @default.
• W1524203595 cites W1982151884 @default.
• W1524203595 cites W2001214801 @default.
• W1524203595 cites W2002385669 @default.
• W1524203595 cites W2012275507 @default.
• W1524203595 cites W2018077130 @default.
• W1524203595 cites W2020463338 @default.
• W1524203595 cites W2020674203 @default.
• W1524203595 cites W2028797537 @default.
• W1524203595 cites W2029126943 @default.
• W1524203595 cites W2031256138 @default.
• W1524203595 cites W2031400649 @default.
• W1524203595 cites W2033641011 @default.
• W1524203595 cites W203445106 @default.
• W1524203595 cites W2040356093 @default.
• W1524203595 cites W2046142879 @default.
• W1524203595 cites W2052686484 @default.
• W1524203595 cites W2053282598 @default.
• W1524203595 cites W2055351375 @default.
• W1524203595 cites W2058891531 @default.
• W1524203595 cites W2059466947 @default.
• W1524203595 cites W2062897412 @default.
• W1524203595 cites W2072405695 @default.
• W1524203595 cites W2073296060 @default.
• W1524203595 cites W2073975174 @default.
• W1524203595 cites W2074595030 @default.
• W1524203595 cites W2076100225 @default.
• W1524203595 cites W2077019107 @default.
• W1524203595 cites W2080515725 @default.
• W1524203595 cites W2084188186 @default.
• W1524203595 cites W2097279301 @default.
• W1524203595 cites W2105369177 @default.
• W1524203595 cites W2116724543 @default.
• W1524203595 cites W2122434665 @default.
• W1524203595 cites W2127090170 @default.
• W1524203595 cites W2129595880 @default.
• W1524203595 cites W2130235475 @default.
• W1524203595 cites W2130672285 @default.
• W1524203595 cites W2134185295 @default.
• W1524203595 cites W2149609246 @default.
• W1524203595 cites W2152488127 @default.
• W1524203595 cites W2153114402 @default.
• W1524203595 cites W2153979876 @default.
• W1524203595 cites W2155084134 @default.
• W1524203595 cites W2163813716 @default.
• W1524203595 cites W2168809362 @default.
• W1524203595 cites W2395363813 @default.
• W1524203595 cites W2395514413 @default.
• W1524203595 cites W2465040478 @default.
• W1524203595 cites W3145828305 @default.
• W1524203595 cites W4206338678 @default.
• W1524203595 cites W4213288087 @default.
• W1524203595 cites W4242871496 @default.
• W1524203595 cites W89412137 @default.
• W1524203595 doi "https://doi.org/10.1002/14651858.cd005604.pub3" @default.
• W1524203595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18425925" @default.
• W1524203595 hasPublicationYear "2008" @default.
• W1524203595 type Work @default.
• W1524203595 sameAs 1524203595 @default.
• W1524203595 citedByCount "27" @default.
• W1524203595 countsByYear W15242035952012 @default.
• W1524203595 countsByYear W15242035952013 @default.
• W1524203595 countsByYear W15242035952015 @default.
• W1524203595 countsByYear W15242035952016 @default.
• W1524203595 countsByYear W15242035952017 @default.
• W1524203595 crossrefType "journal-article" @default.
• W1524203595 hasAuthorship W1524203595A5015755650 @default.
• W1524203595 hasAuthorship W1524203595A5024087517 @default.
• W1524203595 hasAuthorship W1524203595A5060883082 @default.
• W1524203595 hasBestOaLocation W15242035952 @default.
• W1524203595 hasConcept C126322002 @default.
• W1524203595 hasConcept C142724271 @default.
• W1524203595 hasConcept C197934379 @default.
• W1524203595 hasConcept C204787440 @default.
• W1524203595 hasConcept C27081682 @default.
• W1524203595 hasConcept C2776042228 @default.
• W1524203595 hasConcept C2777707825 @default.
• W1524203595 hasConcept C2778338976 @default.
• W1524203595 hasConcept C535046627 @default.
• W1524203595 hasConcept C71924100 @default.
• W1524203595 hasConcept C95190672 @default.
• W1524203595 hasConceptScore W1524203595C126322002 @default.
• W1524203595 hasConceptScore W1524203595C142724271 @default.
• W1524203595 hasConceptScore W1524203595C197934379 @default.
• W1524203595 hasConceptScore W1524203595C204787440 @default.

• next