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• W1524252603 abstract "Peritonitis is a significant complication of peritoneal dialysis (PD) and the most common cause of technique failure. Panton-Valentine leukocidin (PVL), a cytotoxin produced by certain strains of Staphylococcus aureus (SA), causes destruction of neutrophils, and is associated with severe invasive infections. We present a 2.5-year-old girl on PD, who presented suddenly with an unusually fulminant and protracted course of peritonitis. Only a few hours after the onset of clinical signs, septic shock developed. PVL-positive methicillin-sensitive SA (MSSA) was grown and initial empiric antibiotic treatment changed to flucloxacillin and rifampicin in order to minimize toxin production. In spite of adequate antibiotic treatment and PD-catheter removal, recovery was slow. No PD-related peritonitis in children associated with PVL-producing strains have been reported so far and no specific recommendation exists for treatment. We speculate that PVL contributed to the severity and outcome of peritonitis in our patient." @default.
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• W1524252603 date "2013-08-01" @default.
• W1524252603 modified "2023-09-23" @default.
• W1524252603 title "Fulminant Peritonitis Presumably Caused by Panton-Valentine Leukocidin-PositiveStaphylococcus aureusin a Girl on Peritoneal Dialysis" @default.
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• W1524252603 doi "https://doi.org/10.1111/1744-9987.12092" @default.
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