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• W1524252718 abstract "Hepcidin has been identified as the principle regulatory peptide essential for iron homeostasis. Expression of this cysteine-rich peptide is up-regulated by inflammation and iron overload, whereas hypoxia, iron deficiency and erythropoiesis suppress hepcidin expression. The quantitative analysis of hepcidin in bodily fluids will provide an insight into the pathogenesis of disorders of iron metabolism such as hereditary hemochromatosis. A mass spectrometry-based approach was taken to detect and quantify urinary hepcidin as urine is readily available and collection of this sample type is non-invasive. Samples were first purified using micro solid phase extraction (μSPE), followed by matrix assisted laser desorption/ionization-orthogonal-time-of-flight mass spectrometry (MALDI-TOF-MS) with inclusion of an internal standard for the quantitative analysis of unlabelled urinary hepcidin. Monoisotopic resolution of hepcidin-25 was observed with the MALDI-TOF-MS and extraction recovery of more than 70% was achieved. Spot-to-spot variations of less than 3.5% RSD and intraand inter-day precision of less than 9.5% RSD was observed. In our study, average hepcidin-25 levels of 1.7 nmol/mmol creatinine were observed in healthy subjects, compared to an average of 1.1 nmol hepcidin-25/mmol creatinine in" @default.
• W1524252718 created "2016-06-24" @default.
• W1524252718 creator A5040440646 @default.
• W1524252718 date "2010-01-01" @default.
• W1524252718 modified "2023-09-26" @default.
• W1524252718 title "DEVELOPMENT OF A MASS SPECTROMETRY DIAGNOSTIC ASSAY TO MONITOR HEPCIDIN LEVELS IN HEMOCHROMATOSIS PATIENTS" @default.
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