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- W1524300032 abstract "The corpus callosum (CC) plays a crucial role in interhemispheric communication. It has been shown that CC formation relies on the guidepost cells located in the midline region that include glutamatergic and GABAergic neurons as well as glial cells. However, the origin of these guidepost GABAergic neurons and their precise function in callosal axon pathfinding remain to be investigated. Here, we show that two distinct GABAergic neuronal subpopulations converge toward the midline prior to the arrival of callosal axons. Using in vivo and ex vivo fate mapping we show that CC GABAergic neurons originate in the caudal and medial ganglionic eminences (CGE and MGE) but not in the lateral ganglionic eminence (LGE). Time lapse imaging on organotypic slices and in vivo analyses further revealed that CC GABAergic neurons contribute to the normal navigation of callosal axons. The use of Nkx2.1 knockout (KO) mice confirmed a role of these neurons in the maintenance of proper behavior of callosal axons while growing through the CC. Indeed, using in vitro transplantation assays, we demonstrated that both MGE- and CGE-derived GABAergic neurons exert an attractive activity on callosal axons. Furthermore, by combining a sensitive RT-PCR technique with in situ hybridization, we demonstrate that CC neurons express multiple short and long range guidance cues. This study strongly suggests that MGE- and CGE-derived interneurons may guide CC axons by multiple guidance mechanisms and signaling pathways." @default.
- W1524300032 created "2016-06-24" @default.
- W1524300032 creator A5000242339 @default.
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- W1524300032 creator A5020693018 @default.
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- W1524300032 creator A5075365580 @default.
- W1524300032 creator A5090586780 @default.
- W1524300032 date "2013-08-02" @default.
- W1524300032 modified "2023-10-09" @default.
- W1524300032 title "Two specific populations of GABAergic neurons originating from the medial and the caudal ganglionic eminences aid in proper navigation of callosal axons" @default.
- W1524300032 cites W1484893812 @default.
- W1524300032 cites W1491943710 @default.
- W1524300032 cites W1559752086 @default.
- W1524300032 cites W1563901861 @default.
- W1524300032 cites W1589246521 @default.
- W1524300032 cites W166440670 @default.
- W1524300032 cites W1683488899 @default.
- W1524300032 cites W1715204582 @default.
- W1524300032 cites W1952564245 @default.
- W1524300032 cites W1953511915 @default.
- W1524300032 cites W1963788090 @default.
- W1524300032 cites W1968056372 @default.
- W1524300032 cites W1968899084 @default.
- W1524300032 cites W1970400919 @default.
- W1524300032 cites W1970719523 @default.
- W1524300032 cites W1971305731 @default.
- W1524300032 cites W1975767398 @default.
- W1524300032 cites W1983400501 @default.
- W1524300032 cites W1983632203 @default.
- W1524300032 cites W1985360164 @default.
- W1524300032 cites W1988196067 @default.
- W1524300032 cites W1993193182 @default.
- W1524300032 cites W1994124220 @default.
- W1524300032 cites W1996133944 @default.
- W1524300032 cites W2005572805 @default.
- W1524300032 cites W2007648520 @default.
- W1524300032 cites W2010031876 @default.
- W1524300032 cites W2011326452 @default.
- W1524300032 cites W2012481409 @default.
- W1524300032 cites W2012488380 @default.
- W1524300032 cites W2013369476 @default.
- W1524300032 cites W2014651004 @default.
- W1524300032 cites W2018364972 @default.
- W1524300032 cites W2020908159 @default.
- W1524300032 cites W2023368138 @default.
- W1524300032 cites W2023479786 @default.
- W1524300032 cites W2024009242 @default.
- W1524300032 cites W2024642025 @default.
- W1524300032 cites W2031552862 @default.
- W1524300032 cites W2031566177 @default.
- W1524300032 cites W2033712349 @default.
- W1524300032 cites W2036159647 @default.
- W1524300032 cites W2038098373 @default.
- W1524300032 cites W2038465971 @default.
- W1524300032 cites W2049610475 @default.
- W1524300032 cites W2051020842 @default.
- W1524300032 cites W2056304112 @default.
- W1524300032 cites W2056954673 @default.
- W1524300032 cites W2060816347 @default.
- W1524300032 cites W2063183827 @default.
- W1524300032 cites W2067557095 @default.
- W1524300032 cites W2067863368 @default.
- W1524300032 cites W2072583908 @default.
- W1524300032 cites W2076511279 @default.
- W1524300032 cites W2083131697 @default.
- W1524300032 cites W2084114120 @default.
- W1524300032 cites W2084462219 @default.
- W1524300032 cites W2085365459 @default.
- W1524300032 cites W2085408701 @default.
- W1524300032 cites W2086673328 @default.
- W1524300032 cites W2086733183 @default.
- W1524300032 cites W2088556630 @default.
- W1524300032 cites W2093767388 @default.
- W1524300032 cites W2094703740 @default.
- W1524300032 cites W2096679749 @default.
- W1524300032 cites W2097053397 @default.
- W1524300032 cites W2098069596 @default.
- W1524300032 cites W2100057436 @default.
- W1524300032 cites W2106712310 @default.
- W1524300032 cites W2108369365 @default.
- W1524300032 cites W2109627278 @default.
- W1524300032 cites W2111405094 @default.
- W1524300032 cites W2115167653 @default.
- W1524300032 cites W2117719082 @default.
- W1524300032 cites W2117732197 @default.
- W1524300032 cites W2121764727 @default.
- W1524300032 cites W2123766420 @default.
- W1524300032 cites W2125842400 @default.
- W1524300032 cites W2127098199 @default.
- W1524300032 cites W2134711325 @default.
- W1524300032 cites W2135255676 @default.