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- W1524304854 abstract "The recruitment of circulating leukocytes and resident glial cells to sites of CNSinflammation is dependent on the chemokine gradients they encounter and the chemokinereceptors they express. Multiple sclerosis (MS), subacute sclerosing panencephalitis(SSPE) and coeliac disease (CD), with associated neurological complications, areneuroinflammatory diseases with different aetiologies, but which share common CNSneuropathological features including large perivascular inflammatory cell infiltrates,microglial hyperplasia and reactive astrocytosis. The results of this study suggest that inSSPE CNS the interferon -y-inducible a chemokines IP-10 and Mig, predominantlyexpressed by astrocytes and microglia, play a role in lesion formation. In contrast, the schemokineMEP-la, expressed both by perivascular macrophages and resident microglia,plays a role in the recruitment of inflammatory cells into CD cerebellar tissue. The highestlevels of a- and s-chemokine expression were detected in actively demyelinating MSlesions with high levels of inflammation and widespread demyelination. In these lesions,RANTES was predominantly expressed by the endothelium, MCP- l, IP-10 and Mig byreactive astrocytes, and MIP-ls by microglia. These findings suggest not allneuroinflammatory diseases with common pathological features share a commonchemokine profile. The highest level of chemokine receptor expression was also associated withchronic active MS lesions: infiltrating T-lymphocytes predominantly expressing CXCR3and CCR5, and foamy macrophages within the lesion predominantly expressing CCR3,CCR5 and CCR8. In vitro studies confirmed the production of chemokines and theexpression of chemokine receptors by isolated rat astrocytes and microglia followingcytokine stimulation. The results of this study suggest chemokines play a critical role inthe recruitment of cells to sites of inflammation in the CNS." @default.
- W1524304854 created "2016-06-24" @default.
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- W1524304854 date "1999-02-01" @default.
- W1524304854 modified "2023-09-23" @default.
- W1524304854 title "The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases." @default.
- W1524304854 hasPublicationYear "1999" @default.
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