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• W1524337669 abstract "Objectives: To assess whether circulating tumor cells with tumor‐related methylated DNA can be used to predict survival in patients with hormone‐refractory prostate cancer. Methods: Blood samples from 76 patients with hormone‐refractory prostate cancer were analyzed. Circulating tumor cells were enumerated with the CellSearch System in whole blood. This system was developed using an epithelial cell adhesion molecule antibody‐based immunomagnetic capture and automated staining methodology. Hypermethylation at adenomatosis polyposis coli, glutathione‐S‐transferase‐π, prostaglandin‐endoperoxide synthase 2, multidrug resistance 1 and Ras association domain family 1 isoform A was analyzed using a sensitive SYBR green methylation‐specific polymerase chain reaction. Patient charts were retrospectively examined. Results: Median overall survival time was 19.3 months (range 11–48). Of the 76 patients, 47 (62%) had five or more circulating tumor cells, with a median overall survival of 12.0 months compared with 26.0 months for patients with fewer than five circulating tumor cells ( P < 0.001). Circulating tumor cells were detected in 36 of 39 (92%) patients with tumor‐related methylated DNA but only 11 of 37 (30%) patients without methylated DNA ( P < 0.001). Thirty‐nine (51%) patients had one or more methylated marker. Their median overall survival time was 12.0 months compared with 48.0 months or more for patients without methylated DNA ( P < 0.001). Prostate‐specific antigen‐doubling time, circulating tumor cells and methylated DNA were independent predictors of overall survival time. Conclusions: Hormone refractory prostate cancer patients with circulating tumor cells and/or tumor‐related methylated DNA show a significantly poorer outcome than those without these blood markers." @default.
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• W1524337669 date "2010-04-23" @default.
• W1524337669 modified "2023-10-16" @default.
• W1524337669 title "Association of circulating tumor cells with tumor-related methylated DNA in patients with hormone-refractory prostate cancer" @default.
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• W1524337669 doi "https://doi.org/10.1111/j.1442-2042.2010.02502.x" @default.
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