FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1524454925> ?p ?o ?g. }

• W1524454925 endingPage "559" @default.
• W1524454925 startingPage "549" @default.
• W1524454925 abstract "Summary The intracellular pathogen, Salmonella enterica serovar Typhimurium, is able to proliferate in phagocytes, although reactive oxygen and nitrogen intermediates are lethal to most phagocytosed bacteria. To determine whether repair of oxidatively damaged DNA is involved in S. typhimurium intramacrophage proliferation, null mutants of the DNA base excision repair (BER) system were generated. These mutants were deficient in discrete enzymes ( Δnth , Δnei , Δxth , Δnfo ) or in the defined glycosylase ( Δnth/nei ) and endonuclease ( Δxth/nfo ) steps. In this study, S. typhimurium BER mutants are characterized for the first time. In vitro characterization of the Salmonella BER mutants revealed phenotypes that are mostly consistent with characterized Escherichia coli BER mutants. These strains were used to evaluate the role of BER in the context of Salmonella virulence. S. typhimurium Δxth and Δxth/nfo were significantly impaired for survival in both cultured and primary macrophages activated with interferon (IFN)‐γ. Survival of Δxth and Δxth/nfo was improved nearly to wild‐type levels in activated primary macrophages lacking both phagocyte oxidase and inducible nitric oxide synthase. In the murine typhoid fever model, Δnth/nei was fivefold attenuated and Δxth/nfo was 12‐fold attenuated compared with wild type. These data indicate that DNA oxidation is a mechanism that macrophages use to damage intracellular Salmonella , and suggest that BER‐mediated repair of this damage may be important in the establishment of Salmonella infection. We speculate that adaptation to a pathogenic lifestyle may influence the acquisition and retention of redundant BER enzymes." @default.
• W1524454925 created "2016-06-24" @default.
• W1524454925 creator A5002820920 @default.
• W1524454925 creator A5009523661 @default.
• W1524454925 creator A5042679090 @default.
• W1524454925 date "2003-04-01" @default.
• W1524454925 modified "2023-10-14" @default.
• W1524454925 title "The role of DNA base excision repair in the pathogenesis of Salmonella enterica serovar Typhimurium" @default.
• W1524454925 cites W1490937614 @default.
• W1524454925 cites W1540820582 @default.
• W1524454925 cites W1889870303 @default.
• W1524454925 cites W1938034723 @default.
• W1524454925 cites W1939685797 @default.
• W1524454925 cites W1973711487 @default.
• W1524454925 cites W1989599765 @default.
• W1524454925 cites W1992144107 @default.
• W1524454925 cites W1992584287 @default.
• W1524454925 cites W1995658707 @default.
• W1524454925 cites W2006614927 @default.
• W1524454925 cites W2016419647 @default.
• W1524454925 cites W2021338740 @default.
• W1524454925 cites W2023822923 @default.
• W1524454925 cites W2027989895 @default.
• W1524454925 cites W2030477444 @default.
• W1524454925 cites W2032078625 @default.
• W1524454925 cites W2052562838 @default.
• W1524454925 cites W2054573707 @default.
• W1524454925 cites W2066732573 @default.
• W1524454925 cites W2078637161 @default.
• W1524454925 cites W2096089218 @default.
• W1524454925 cites W2096212458 @default.
• W1524454925 cites W2097466384 @default.
• W1524454925 cites W2109547243 @default.
• W1524454925 cites W2109626244 @default.
• W1524454925 cites W2111176922 @default.
• W1524454925 cites W2113120391 @default.
• W1524454925 cites W2123680076 @default.
• W1524454925 cites W2125808742 @default.
• W1524454925 cites W2126234020 @default.
• W1524454925 cites W2132054156 @default.
• W1524454925 cites W2133100152 @default.
• W1524454925 cites W2135004245 @default.
• W1524454925 cites W2138241883 @default.
• W1524454925 cites W2144880990 @default.
• W1524454925 cites W2162429416 @default.
• W1524454925 cites W2163076785 @default.
• W1524454925 cites W2163136815 @default.
• W1524454925 cites W2163392206 @default.
• W1524454925 cites W2167545117 @default.
• W1524454925 cites W296954764 @default.
• W1524454925 cites W4232892597 @default.
• W1524454925 doi "https://doi.org/10.1046/j.1365-2958.2003.03460.x" @default.
• W1524454925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12675811" @default.
• W1524454925 hasPublicationYear "2003" @default.
• W1524454925 type Work @default.
• W1524454925 sameAs 1524454925 @default.
• W1524454925 citedByCount "60" @default.
• W1524454925 countsByYear W15244549252012 @default.
• W1524454925 countsByYear W15244549252013 @default.
• W1524454925 countsByYear W15244549252014 @default.
• W1524454925 countsByYear W15244549252015 @default.
• W1524454925 countsByYear W15244549252016 @default.
• W1524454925 countsByYear W15244549252017 @default.
• W1524454925 countsByYear W15244549252019 @default.
• W1524454925 countsByYear W15244549252020 @default.
• W1524454925 countsByYear W15244549252021 @default.
• W1524454925 countsByYear W15244549252023 @default.
• W1524454925 crossrefType "journal-article" @default.
• W1524454925 hasAuthorship W1524454925A5002820920 @default.
• W1524454925 hasAuthorship W1524454925A5009523661 @default.
• W1524454925 hasAuthorship W1524454925A5042679090 @default.
• W1524454925 hasBestOaLocation W15244549251 @default.
• W1524454925 hasConcept C104317684 @default.
• W1524454925 hasConcept C134935766 @default.
• W1524454925 hasConcept C143065580 @default.
• W1524454925 hasConcept C143425029 @default.
• W1524454925 hasConcept C153911025 @default.
• W1524454925 hasConcept C187206112 @default.
• W1524454925 hasConcept C2778910516 @default.
• W1524454925 hasConcept C2779607309 @default.
• W1524454925 hasConcept C2781065037 @default.
• W1524454925 hasConcept C523546767 @default.
• W1524454925 hasConcept C54355233 @default.
• W1524454925 hasConcept C547475151 @default.
• W1524454925 hasConcept C552990157 @default.
• W1524454925 hasConcept C55493867 @default.
• W1524454925 hasConcept C86803240 @default.
• W1524454925 hasConcept C89423630 @default.
• W1524454925 hasConceptScore W1524454925C104317684 @default.
• W1524454925 hasConceptScore W1524454925C134935766 @default.
• W1524454925 hasConceptScore W1524454925C143065580 @default.
• W1524454925 hasConceptScore W1524454925C143425029 @default.
• W1524454925 hasConceptScore W1524454925C153911025 @default.
• W1524454925 hasConceptScore W1524454925C187206112 @default.
• W1524454925 hasConceptScore W1524454925C2778910516 @default.
• W1524454925 hasConceptScore W1524454925C2779607309 @default.
• W1524454925 hasConceptScore W1524454925C2781065037 @default.
• W1524454925 hasConceptScore W1524454925C523546767 @default.

• next