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- W1524492065 abstract "S100A6 is a member of the S100 family of Ca2+ binding proteins, which have come to play an important role in the diagnosis of cancer due to their overexpression in various tumor cells. We have determined the crystal structures of human S100A6 in the Ca2+-free and Ca2+-bound states to resolutions of 1.15 Å and 1.44 Å, respectively. Ca2+ binding is responsible for a dramatic change in the global shape and charge distribution of the S100A6 dimer, leading to the exposure of two symmetrically positioned target binding sites. The results are consistent with S100A6, and most likely other S100 proteins, functioning as Ca2+ sensors in a way analogous to the prototypical sensors calmodulin and troponin C. The structures have important implications for our understanding of target binding and cooperativity of Ca2+ binding in the S100 family." @default.
- W1524492065 created "2016-06-24" @default.
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- W1524492065 date "2002-04-01" @default.
- W1524492065 modified "2023-10-03" @default.
- W1524492065 title "Crystal Structures of S100A6 in the Ca2+-Free and Ca2+-Bound States" @default.
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- W1524492065 doi "https://doi.org/10.1016/s0969-2126(02)00740-2" @default.
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