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- W1524572279 abstract "Changes in regional cerebral blood flow (rCBF) and glucose metabolism are commonly associated with traumatic brain injury (TBI). Reactive oxygen species (ROS) have been implicated as key contributors to the secondary injury process after TBI. Here, pretreatment with the nitrone radical scavengers (alpha-phenyl-N-tert-butyl nitrone (PBN) or its sulfonated analogue sodium 2-sulfophenyl-N-tert-butyl nitrone (S-PBN) were used as tools to study the effects of ROS on rCBF and glucose metabolism after moderate (2.4-2.6 atm) lateral fluid percussion injury (FPI) in rats. S-PBN has a half-life in plasma of 9 min and does not penetrate the blood-brain barrier (BBB). In contrast, PBN has a half-life of 3 h and readily penetrates the BBB. Regional cerebral blood flow (rCBF) and glucose metabolism was estimated by using (99m)Tc-HMPAO and [(18)F]Fluoro-2-deoxyglucose (FDG) autoradiography, respectively, at 42 min (n = 37) and 12 h (n = 34) after the injury. Regions of interest were the parietal cortex and hippocampus bilaterally. As expected, FPI produced an early (42-min) hypoperfusion in ipsilateral cortex and an increase in glucose metabolism in both cortex and hippocampus, giving way to a state of hypoperfusion and decreased glucose metabolism at 12 h postinjury. On the contralateral side, a hypoperfusion in the cortex and hippocampus was seen at 12 h only, but no significant changes in glucose metabolism. Both S-PBN and PBN attenuated the trauma-induced changes in rCBF and glucose metabolism. Thus, the early improvement in rCBF and glucose metabolism correlates with and may partly mediate the improved functional and morphological outcome after TBI in nitrone-treated rats." @default.
- W1524572279 created "2016-06-24" @default.
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- W1524572279 creator A5050853855 @default.
- W1524572279 creator A5062898791 @default.
- W1524572279 date "2002-10-01" @default.
- W1524572279 modified "2023-09-27" @default.
- W1524572279 title "Effect of Traumatic Brain Injury and Nitrone Radical Scavengers on Relative Changes in Regional Cerebral Blood Flow and Glucose Uptake in Rats" @default.
- W1524572279 cites W1520169101 @default.
- W1524572279 cites W1591346556 @default.
- W1524572279 cites W16030070 @default.
- W1524572279 cites W16603568 @default.
- W1524572279 cites W1757543239 @default.
- W1524572279 cites W1810236234 @default.
- W1524572279 cites W1821918060 @default.
- W1524572279 cites W1963689012 @default.
- W1524572279 cites W1966191914 @default.
- W1524572279 cites W1966558330 @default.
- W1524572279 cites W1967523914 @default.
- W1524572279 cites W1969445752 @default.
- W1524572279 cites W1970392661 @default.
- W1524572279 cites W1974182326 @default.
- W1524572279 cites W1979362523 @default.
- W1524572279 cites W1979470828 @default.
- W1524572279 cites W1979824327 @default.
- W1524572279 cites W1980818239 @default.
- W1524572279 cites W1985555928 @default.
- W1524572279 cites W1985944040 @default.
- W1524572279 cites W1987018561 @default.
- W1524572279 cites W1987036493 @default.
- W1524572279 cites W1987532040 @default.
- W1524572279 cites W1987999833 @default.
- W1524572279 cites W1989378067 @default.
- W1524572279 cites W1990285030 @default.
- W1524572279 cites W1994909968 @default.
- W1524572279 cites W2003147009 @default.
- W1524572279 cites W2003213627 @default.
- W1524572279 cites W2004985736 @default.
- W1524572279 cites W2005606566 @default.
- W1524572279 cites W2007348580 @default.
- W1524572279 cites W2012370852 @default.
- W1524572279 cites W2016871397 @default.
- W1524572279 cites W2023965523 @default.
- W1524572279 cites W2024267786 @default.
- W1524572279 cites W2025640911 @default.
- W1524572279 cites W2027006803 @default.
- W1524572279 cites W2027901535 @default.
- W1524572279 cites W2033573399 @default.
- W1524572279 cites W2034668199 @default.
- W1524572279 cites W2036393894 @default.
- W1524572279 cites W2040685668 @default.
- W1524572279 cites W2041204070 @default.
- W1524572279 cites W2045410354 @default.
- W1524572279 cites W2045902250 @default.
- W1524572279 cites W2046613651 @default.
- W1524572279 cites W2047296068 @default.
- W1524572279 cites W2047797594 @default.
- W1524572279 cites W2047906602 @default.
- W1524572279 cites W2049189117 @default.
- W1524572279 cites W2049428746 @default.
- W1524572279 cites W2051221319 @default.
- W1524572279 cites W2051600991 @default.
- W1524572279 cites W2052862743 @default.
- W1524572279 cites W2056180447 @default.
- W1524572279 cites W2057621984 @default.
- W1524572279 cites W2059580764 @default.
- W1524572279 cites W2060143794 @default.
- W1524572279 cites W2067682780 @default.
- W1524572279 cites W2068121825 @default.
- W1524572279 cites W2070719568 @default.
- W1524572279 cites W2072643276 @default.
- W1524572279 cites W2074595931 @default.
- W1524572279 cites W2087916050 @default.
- W1524572279 cites W2088889090 @default.
- W1524572279 cites W2090306035 @default.
- W1524572279 cites W2090544950 @default.
- W1524572279 cites W2091112040 @default.
- W1524572279 cites W2092116887 @default.
- W1524572279 cites W2092434834 @default.
- W1524572279 cites W2092553541 @default.
- W1524572279 cites W2094544671 @default.
- W1524572279 cites W2105215015 @default.
- W1524572279 cites W2105534568 @default.
- W1524572279 cites W2114488851 @default.
- W1524572279 cites W2123351961 @default.
- W1524572279 cites W2131004204 @default.
- W1524572279 cites W2135781323 @default.
- W1524572279 cites W2142084940 @default.
- W1524572279 cites W2165083422 @default.
- W1524572279 cites W2171723910 @default.
- W1524572279 cites W2202491923 @default.
- W1524572279 cites W2408466116 @default.
- W1524572279 doi "https://doi.org/10.1089/08977150260337958" @default.
- W1524572279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12427324" @default.
- W1524572279 hasPublicationYear "2002" @default.
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