Matches in SemOpenAlex for { <https://semopenalex.org/work/W1524574498> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1524574498 endingPage "372" @default.
- W1524574498 startingPage "367" @default.
- W1524574498 abstract "Abstract The effects of 5-iodo-2'-deoxyuridine, 5-bromo-2'-deoxyuridine, 5-chloro-2'-deoxyuridine, 5-fluoro-2'-deoxyuridine, and 3-N-methyl-5-iodo-2'-deoxyuridine, a new analog of thymidine, on the ultraviolet (UV) inactivation of thymidine kinase have been investigated. Of these compounds only 5-iodo-2'-deoxyuridine and 3-N-methyl-5-iodo-2'-deoxyuridine enhance the rate of inactivation of the enzyme by UV light. The other halogenated analogs neither protect nor sensitize thymidine kinase to UV inactivation. Whereas the inactivation of thymidine kinase by UV light in the presence of 5-iodo-2'-deoxyuridine can be prevented by the substrate, thymidine (Cysyk, R., and Prusoff, W. H. (1969) Fed. Proc., 28, 473; Cysyk, R. (1970) Ph.D. thesis, Yale University), that produced by 3-N-methyl-5-iodo-2'-deoxyuridine is not prevented by thymidine alone but requires the presence of both substrates, thymidine and MgATP. Kinetic studies with thymidine kinase show 5-iodo-2'-deoxyuridine to be a competitive inhibitor with respect to thymidine; however, 3-N-methyl-5-iodo-2'-deoxyuridine shows uncompetitive inhibition with thymidine and competitive inhibition with MgATP. The allosteric regulators, dCDP, an activator, and dTTP, an inhibitor, protect the enzyme against UV irradiation and decrease the rate of inactivation caused by 3-N-methyl-5-iodo-2'-deoxyuridine. The primary photostable compound formed during photolysis of 3-N-methyl-5-iodo-2'-deoxyuridine appears to be 3-N-methyl deoxyuridine, which is analogous to the formation of deoxyuridine during photolysis of 5-iodo-2'-deoxyuridine (Cysyk, R. (1970) Ph.D. thesis, Yale University)." @default.
- W1524574498 created "2016-06-24" @default.
- W1524574498 creator A5013228826 @default.
- W1524574498 creator A5049792620 @default.
- W1524574498 creator A5051415201 @default.
- W1524574498 date "1972-01-01" @default.
- W1524574498 modified "2023-09-29" @default.
- W1524574498 title "Kinetic and Photochemical Studies of 3-N-Methyl-5-iodo-2′-deoxyuridine" @default.
- W1524574498 cites W1483183063 @default.
- W1524574498 cites W1570780814 @default.
- W1524574498 cites W1964051444 @default.
- W1524574498 cites W1978890409 @default.
- W1524574498 cites W2011597849 @default.
- W1524574498 cites W2016245677 @default.
- W1524574498 cites W2021047971 @default.
- W1524574498 cites W2022026416 @default.
- W1524574498 cites W2036863313 @default.
- W1524574498 cites W2053066037 @default.
- W1524574498 cites W2053710767 @default.
- W1524574498 cites W2070802418 @default.
- W1524574498 cites W2072293459 @default.
- W1524574498 cites W2073084767 @default.
- W1524574498 cites W2076304440 @default.
- W1524574498 cites W2082447949 @default.
- W1524574498 cites W2090110255 @default.
- W1524574498 cites W2091288411 @default.
- W1524574498 cites W2140644923 @default.
- W1524574498 cites W2151246853 @default.
- W1524574498 cites W2175582194 @default.
- W1524574498 cites W2624110154 @default.
- W1524574498 doi "https://doi.org/10.1016/s0021-9258(19)45713-x" @default.
- W1524574498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4257923" @default.
- W1524574498 hasPublicationYear "1972" @default.
- W1524574498 type Work @default.
- W1524574498 sameAs 1524574498 @default.
- W1524574498 citedByCount "17" @default.
- W1524574498 crossrefType "journal-article" @default.
- W1524574498 hasAuthorship W1524574498A5013228826 @default.
- W1524574498 hasAuthorship W1524574498A5049792620 @default.
- W1524574498 hasAuthorship W1524574498A5051415201 @default.
- W1524574498 hasBestOaLocation W15245744981 @default.
- W1524574498 hasConcept C121332964 @default.
- W1524574498 hasConcept C135889238 @default.
- W1524574498 hasConcept C155647269 @default.
- W1524574498 hasConcept C185592680 @default.
- W1524574498 hasConcept C2777111502 @default.
- W1524574498 hasConcept C552990157 @default.
- W1524574498 hasConcept C55493867 @default.
- W1524574498 hasConcept C62520636 @default.
- W1524574498 hasConcept C71240020 @default.
- W1524574498 hasConcept C75473681 @default.
- W1524574498 hasConceptScore W1524574498C121332964 @default.
- W1524574498 hasConceptScore W1524574498C135889238 @default.
- W1524574498 hasConceptScore W1524574498C155647269 @default.
- W1524574498 hasConceptScore W1524574498C185592680 @default.
- W1524574498 hasConceptScore W1524574498C2777111502 @default.
- W1524574498 hasConceptScore W1524574498C552990157 @default.
- W1524574498 hasConceptScore W1524574498C55493867 @default.
- W1524574498 hasConceptScore W1524574498C62520636 @default.
- W1524574498 hasConceptScore W1524574498C71240020 @default.
- W1524574498 hasConceptScore W1524574498C75473681 @default.
- W1524574498 hasIssue "2" @default.
- W1524574498 hasLocation W15245744981 @default.
- W1524574498 hasOpenAccess W1524574498 @default.
- W1524574498 hasPrimaryLocation W15245744981 @default.
- W1524574498 hasRelatedWork W2044222210 @default.
- W1524574498 hasRelatedWork W2315647579 @default.
- W1524574498 hasRelatedWork W2329438784 @default.
- W1524574498 hasRelatedWork W2605421943 @default.
- W1524574498 hasRelatedWork W2605598762 @default.
- W1524574498 hasRelatedWork W2605633184 @default.
- W1524574498 hasRelatedWork W2606081567 @default.
- W1524574498 hasRelatedWork W2606340465 @default.
- W1524574498 hasRelatedWork W2951104772 @default.
- W1524574498 hasRelatedWork W2508177604 @default.
- W1524574498 hasVolume "247" @default.
- W1524574498 isParatext "false" @default.
- W1524574498 isRetracted "false" @default.
- W1524574498 magId "1524574498" @default.
- W1524574498 workType "article" @default.