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- W1524764115 abstract "Studies were made on the association of the SH-blocking effect of Diazo-ICA with its activity in releasing 5-HT from isolated rabbit platelets, and the releasing activity was compared with that of NEM. High concentration of NEM, like Diazo-ICA, caused release of 5-HT from platelets, but, unlike Diazo-ICA, its action was independent of the calcium ion concentration in the incubation medium. The calcium-dependent release of 5-HT by Diazo-ICA was completely blocked by a small amount of NEM. The sulfhydryl compounds, cysteine, glutathione and BAL also blocked release of 5-HT by Diazo-ICA. ATP, ADP and inorganic pyrophosphate inhibited release of 5-HT by Diazo-ICA, but AMP and creatine phosphate did not. These findings suggest that the sulfhydryl group and pyrophosphate structures are involved in the mechanism of release of 5-HT from rabbit platelets by Diazo-ICA." @default.
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- W1524764115 date "1971-02-01" @default.
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- W1524764115 title "Biological activity of diazonium compounds. Studies on the mechanism of action of 4 (or 5)-diazoimidazole-5 (or 4)-carboxamide on 5-hydroxytrypt-amine release from rabbit platelets—II" @default.
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- W1524764115 doi "https://doi.org/10.1016/0006-2952(71)90064-5" @default.
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