Matches in SemOpenAlex for { <https://semopenalex.org/work/W1524854414> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1524854414 endingPage "188" @default.
- W1524854414 startingPage "173" @default.
- W1524854414 abstract "Publisher Summary This chapter discusses the thiocarbamoylating properties of 1,3-bis(2-chloroethyl)-l-nitrosourea (BCNU or carmustine). BCNU is a widely used cytostatic drug with activity against brain tumors, lymphomas, leukemia, malignant melanoma, and other neoplasms. In aqueous solution, depending on pH and buffer, BCNU disintegrates slowly into numerous products. The first step of decomposition results in the formation of two electrophilic reactants: the bifunctional alkylating 2-chloroethyl diazohydroxide and the carbamoylating chloroethyl isocyanate. DNA-alkylating and DNA cross-linking derivatives of the diazohydroxide largely mediate the cytostatic effects. Additional mechanisms of BCNU action have been proposed, notably the inhibition of glutathione reductase and the carbamoylation of glutathione (GSH), which yields S -[ N -2-(chloroethyl)carbamoyl] glutathione. This compound can be regarded as the carrier of reactive BCNU derivatives. The carbamoylating potential of BCNU contributes both to the desired effects and to the risks of the drug, which include pulmonary fibrosis, bone marrow toxicity, cataract formation, hemolytic crises, and secondary tumors. The chapter discusses the BCNU decomposition product 2-chloroethyl isocyanate, BCNU as inhibitor of glutathione reductase, inhibition of other enzymes by BCNU, revelation of oxidative stress by inhibiting the glutathione redox cycle, and formation and reactions of S -[ N -2-(chloroethyl)carbamoyl]-glutathione." @default.
- W1524854414 created "2016-06-24" @default.
- W1524854414 creator A5047628393 @default.
- W1524854414 creator A5056324322 @default.
- W1524854414 date "1995-01-01" @default.
- W1524854414 modified "2023-10-13" @default.
- W1524854414 title "[15] 1,3-Bis(2-chloroethyl)-1-nitrosourea as Thiol-carbamoylating agent in biological Systems" @default.
- W1524854414 cites W1548131797 @default.
- W1524854414 cites W1570945237 @default.
- W1524854414 cites W1680863695 @default.
- W1524854414 cites W1965704154 @default.
- W1524854414 cites W1979918834 @default.
- W1524854414 cites W1983678579 @default.
- W1524854414 cites W2000387947 @default.
- W1524854414 cites W2003152065 @default.
- W1524854414 cites W2006370393 @default.
- W1524854414 cites W2022405954 @default.
- W1524854414 cites W2026463057 @default.
- W1524854414 cites W2027579720 @default.
- W1524854414 cites W2035595128 @default.
- W1524854414 cites W2048396320 @default.
- W1524854414 cites W2061835032 @default.
- W1524854414 cites W2080370847 @default.
- W1524854414 cites W2136935856 @default.
- W1524854414 cites W2144872557 @default.
- W1524854414 cites W2250064791 @default.
- W1524854414 cites W2277851664 @default.
- W1524854414 cites W2279065740 @default.
- W1524854414 cites W2314655575 @default.
- W1524854414 cites W2797857252 @default.
- W1524854414 cites W2800252050 @default.
- W1524854414 cites W394249887 @default.
- W1524854414 doi "https://doi.org/10.1016/0076-6879(95)51120-2" @default.
- W1524854414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7651196" @default.
- W1524854414 hasPublicationYear "1995" @default.
- W1524854414 type Work @default.
- W1524854414 sameAs 1524854414 @default.
- W1524854414 citedByCount "49" @default.
- W1524854414 countsByYear W15248544142014 @default.
- W1524854414 countsByYear W15248544142021 @default.
- W1524854414 crossrefType "book-chapter" @default.
- W1524854414 hasAuthorship W1524854414A5047628393 @default.
- W1524854414 hasAuthorship W1524854414A5056324322 @default.
- W1524854414 hasConcept C185592680 @default.
- W1524854414 hasConcept C2776694085 @default.
- W1524854414 hasConcept C2776946711 @default.
- W1524854414 hasConcept C2781324293 @default.
- W1524854414 hasConcept C41008148 @default.
- W1524854414 hasConcept C54355233 @default.
- W1524854414 hasConcept C55493867 @default.
- W1524854414 hasConcept C86803240 @default.
- W1524854414 hasConceptScore W1524854414C185592680 @default.
- W1524854414 hasConceptScore W1524854414C2776694085 @default.
- W1524854414 hasConceptScore W1524854414C2776946711 @default.
- W1524854414 hasConceptScore W1524854414C2781324293 @default.
- W1524854414 hasConceptScore W1524854414C41008148 @default.
- W1524854414 hasConceptScore W1524854414C54355233 @default.
- W1524854414 hasConceptScore W1524854414C55493867 @default.
- W1524854414 hasConceptScore W1524854414C86803240 @default.
- W1524854414 hasLocation W15248544141 @default.
- W1524854414 hasLocation W15248544142 @default.
- W1524854414 hasOpenAccess W1524854414 @default.
- W1524854414 hasPrimaryLocation W15248544141 @default.
- W1524854414 hasRelatedWork W1531601525 @default.
- W1524854414 hasRelatedWork W2319480705 @default.
- W1524854414 hasRelatedWork W2384464875 @default.
- W1524854414 hasRelatedWork W2606230654 @default.
- W1524854414 hasRelatedWork W2607424097 @default.
- W1524854414 hasRelatedWork W2748952813 @default.
- W1524854414 hasRelatedWork W2899084033 @default.
- W1524854414 hasRelatedWork W2948807893 @default.
- W1524854414 hasRelatedWork W4387497383 @default.
- W1524854414 hasRelatedWork W2778153218 @default.
- W1524854414 isParatext "false" @default.
- W1524854414 isRetracted "false" @default.
- W1524854414 magId "1524854414" @default.
- W1524854414 workType "book-chapter" @default.