Matches in SemOpenAlex for { <https://semopenalex.org/work/W1524972015> ?p ?o ?g. }
- W1524972015 endingPage "2447" @default.
- W1524972015 startingPage "2440" @default.
- W1524972015 abstract "BACKGROUND Recently, isocitrate dehydrogenase 1 ( IDH1 ) was identified as a major participant in glioma pathogenesis. At present, the enzymatic activity of the protein has been the main topic in investigating its physiological function, but its signaling pathway allocation was unsuccessful. Interestingly, proteins regulated by phosphoinositide 3‐kinase (PI3K)/Akt signaling, are among the top downregulated genes in gliomas associated with high percentage of IDH1 and IDH2 mutations. The aim of this study was to investigate a hypothetical relation between IDH1 and PI3K signaling. METHODS The presence of mutant IDH1 and markers for active PI3K/Akt signaling, present as phosphorylated Akt and podoplanin (PDPN), were investigated in a discovery cohort of 354 patients with glioma. In vitro experiments were used to confirm functional links. RESULTS This study shows an inverse correlation between mutant IDH1 and markers for active PI3K/Akt signaling. In support of a functional link between these molecules, in vitro expression of mutant IDH1 inhibited Akt phosphorylation in a 2‐hydroxyglutarate–dependent manner. CONCLUSIONS This study provides patient tumor and in vitro evidence suggesting that mutant IDH1 inhibits PI3K/Akt signaling. Cancer 2014;120:2440–2447 . © 2014 American Cancer Society ." @default.
- W1524972015 created "2016-06-24" @default.
- W1524972015 creator A5004114090 @default.
- W1524972015 creator A5006973314 @default.
- W1524972015 creator A5017976894 @default.
- W1524972015 creator A5018138289 @default.
- W1524972015 creator A5030008899 @default.
- W1524972015 creator A5039119764 @default.
- W1524972015 creator A5044894547 @default.
- W1524972015 creator A5057631651 @default.
- W1524972015 creator A5081984417 @default.
- W1524972015 creator A5086699505 @default.
- W1524972015 creator A5091374128 @default.
- W1524972015 date "2014-04-25" @default.
- W1524972015 modified "2023-10-07" @default.
- W1524972015 title "Mutant IDH1 inhibits PI3K/Akt signaling in human glioma" @default.
- W1524972015 cites W1964150693 @default.
- W1524972015 cites W1977267072 @default.
- W1524972015 cites W1988756388 @default.
- W1524972015 cites W1996484632 @default.
- W1524972015 cites W1997502785 @default.
- W1524972015 cites W2011376261 @default.
- W1524972015 cites W2019768326 @default.
- W1524972015 cites W2029445248 @default.
- W1524972015 cites W2040827479 @default.
- W1524972015 cites W2047867594 @default.
- W1524972015 cites W2071067115 @default.
- W1524972015 cites W2080452140 @default.
- W1524972015 cites W2091977407 @default.
- W1524972015 cites W2096796171 @default.
- W1524972015 cites W2105528101 @default.
- W1524972015 cites W2119000874 @default.
- W1524972015 cites W2126817554 @default.
- W1524972015 cites W2128207422 @default.
- W1524972015 cites W2134061682 @default.
- W1524972015 cites W2135291999 @default.
- W1524972015 cites W2142160388 @default.
- W1524972015 cites W2149363397 @default.
- W1524972015 cites W2151853926 @default.
- W1524972015 cites W2154313451 @default.
- W1524972015 cites W2160102037 @default.
- W1524972015 cites W2168784615 @default.
- W1524972015 cites W2169472843 @default.
- W1524972015 cites W2469704878 @default.
- W1524972015 doi "https://doi.org/10.1002/cncr.28732" @default.
- W1524972015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24771584" @default.
- W1524972015 hasPublicationYear "2014" @default.
- W1524972015 type Work @default.
- W1524972015 sameAs 1524972015 @default.
- W1524972015 citedByCount "39" @default.
- W1524972015 countsByYear W15249720152014 @default.
- W1524972015 countsByYear W15249720152015 @default.
- W1524972015 countsByYear W15249720152016 @default.
- W1524972015 countsByYear W15249720152017 @default.
- W1524972015 countsByYear W15249720152018 @default.
- W1524972015 countsByYear W15249720152019 @default.
- W1524972015 countsByYear W15249720152020 @default.
- W1524972015 countsByYear W15249720152021 @default.
- W1524972015 countsByYear W15249720152022 @default.
- W1524972015 countsByYear W15249720152023 @default.
- W1524972015 crossrefType "journal-article" @default.
- W1524972015 hasAuthorship W1524972015A5004114090 @default.
- W1524972015 hasAuthorship W1524972015A5006973314 @default.
- W1524972015 hasAuthorship W1524972015A5017976894 @default.
- W1524972015 hasAuthorship W1524972015A5018138289 @default.
- W1524972015 hasAuthorship W1524972015A5030008899 @default.
- W1524972015 hasAuthorship W1524972015A5039119764 @default.
- W1524972015 hasAuthorship W1524972015A5044894547 @default.
- W1524972015 hasAuthorship W1524972015A5057631651 @default.
- W1524972015 hasAuthorship W1524972015A5081984417 @default.
- W1524972015 hasAuthorship W1524972015A5086699505 @default.
- W1524972015 hasAuthorship W1524972015A5091374128 @default.
- W1524972015 hasBestOaLocation W15249720151 @default.
- W1524972015 hasConcept C104317684 @default.
- W1524972015 hasConcept C11960822 @default.
- W1524972015 hasConcept C127848430 @default.
- W1524972015 hasConcept C143065580 @default.
- W1524972015 hasConcept C181199279 @default.
- W1524972015 hasConcept C2777150147 @default.
- W1524972015 hasConcept C2778227246 @default.
- W1524972015 hasConcept C502942594 @default.
- W1524972015 hasConcept C55493867 @default.
- W1524972015 hasConcept C62478195 @default.
- W1524972015 hasConcept C75217442 @default.
- W1524972015 hasConcept C86554907 @default.
- W1524972015 hasConcept C86803240 @default.
- W1524972015 hasConcept C95444343 @default.
- W1524972015 hasConceptScore W1524972015C104317684 @default.
- W1524972015 hasConceptScore W1524972015C11960822 @default.
- W1524972015 hasConceptScore W1524972015C127848430 @default.
- W1524972015 hasConceptScore W1524972015C143065580 @default.
- W1524972015 hasConceptScore W1524972015C181199279 @default.
- W1524972015 hasConceptScore W1524972015C2777150147 @default.
- W1524972015 hasConceptScore W1524972015C2778227246 @default.
- W1524972015 hasConceptScore W1524972015C502942594 @default.
- W1524972015 hasConceptScore W1524972015C55493867 @default.
- W1524972015 hasConceptScore W1524972015C62478195 @default.
- W1524972015 hasConceptScore W1524972015C75217442 @default.