FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525028622> ?p ?o ?g. }

• W1525028622 abstract "Abstract Background Owing to the explosion of information generated by human genomics, analysis of publicly available databases can help identify potential candidate genes relevant to the cancerous phenotype. The aim of this study was to scan for such genes by whole-genome in silico subtraction using Expressed Sequence Tag (EST) data. Methods Genes differentially expressed in normal versus tumor tissues were identified using a computer-based differential display strategy. Bcl-xL, an anti-apoptotic member of the Bcl-2 family, was selected for confirmation by western blot analysis. Results Our genome-wide expression analysis identified a set of genes whose differential expression may be attributed to the genetic alterations associated with tumor formation and malignant growth. We propose complete lists of genes that may serve as targets for projects seeking novel candidates for cancer diagnosis and therapy. Our validation result showed increased protein levels of Bcl-xL in two different liver cancer specimens compared to normal liver. Notably, our EST-based data mining procedure indicated that most of the changes in gene expression observed in cancer cells corresponded to gene inactivation patterns. Chromosomes and chromosomal regions most frequently associated with aberrant expression changes in cancer libraries were also determined. Conclusion Through the description of several candidates (including genes encoding extracellular matrix and ribosomal components, cytoskeletal proteins, apoptotic regulators, and novel tissue-specific biomarkers), our study illustrates the utility of in silico transcriptomics to identify tumor cell signatures, tumor-related genes and chromosomal regions frequently associated with aberrant expression in cancer." @default.
• W1525028622 created "2016-06-24" @default.
• W1525028622 creator A5002553667 @default.
• W1525028622 creator A5004343368 @default.
• W1525028622 creator A5015988270 @default.
• W1525028622 creator A5045640553 @default.
• W1525028622 creator A5075335031 @default.
• W1525028622 date "2006-04-26" @default.
• W1525028622 modified "2023-10-16" @default.
• W1525028622 title "Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues" @default.
• W1525028622 cites W1714044612 @default.
• W1525028622 cites W1968592882 @default.
• W1525028622 cites W1969876234 @default.
• W1525028622 cites W1977966822 @default.
• W1525028622 cites W1984282920 @default.
• W1525028622 cites W1993899393 @default.
• W1525028622 cites W1994468555 @default.
• W1525028622 cites W2002129512 @default.
• W1525028622 cites W2016027155 @default.
• W1525028622 cites W2016726449 @default.
• W1525028622 cites W2018120488 @default.
• W1525028622 cites W2027111364 @default.
• W1525028622 cites W2028807366 @default.
• W1525028622 cites W2035341801 @default.
• W1525028622 cites W2049814842 @default.
• W1525028622 cites W2050343412 @default.
• W1525028622 cites W2054036469 @default.
• W1525028622 cites W2060630781 @default.
• W1525028622 cites W2069448949 @default.
• W1525028622 cites W2073915650 @default.
• W1525028622 cites W2092108654 @default.
• W1525028622 cites W2126360553 @default.
• W1525028622 cites W2129495190 @default.
• W1525028622 cites W2130189476 @default.
• W1525028622 cites W2131027119 @default.
• W1525028622 cites W2142993725 @default.
• W1525028622 cites W2147141733 @default.
• W1525028622 cites W2152365292 @default.
• W1525028622 cites W2158714788 @default.
• W1525028622 cites W2315772961 @default.
• W1525028622 cites W2324384090 @default.
• W1525028622 cites W3095351243 @default.
• W1525028622 cites W4238829989 @default.
• W1525028622 cites W4299351403 @default.
• W1525028622 cites W56887765 @default.
• W1525028622 doi "https://doi.org/10.1186/1471-2164-7-94" @default.
• W1525028622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1459866" @default.
• W1525028622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16640784" @default.
• W1525028622 hasPublicationYear "2006" @default.
• W1525028622 type Work @default.
• W1525028622 sameAs 1525028622 @default.
• W1525028622 citedByCount "18" @default.
• W1525028622 countsByYear W15250286222013 @default.
• W1525028622 countsByYear W15250286222014 @default.
• W1525028622 countsByYear W15250286222019 @default.
• W1525028622 crossrefType "journal-article" @default.
• W1525028622 hasAuthorship W1525028622A5002553667 @default.
• W1525028622 hasAuthorship W1525028622A5004343368 @default.
• W1525028622 hasAuthorship W1525028622A5015988270 @default.
• W1525028622 hasAuthorship W1525028622A5045640553 @default.
• W1525028622 hasAuthorship W1525028622A5075335031 @default.
• W1525028622 hasBestOaLocation W15250286221 @default.
• W1525028622 hasConcept C104317684 @default.
• W1525028622 hasConcept C121608353 @default.
• W1525028622 hasConcept C127716648 @default.
• W1525028622 hasConcept C141231307 @default.
• W1525028622 hasConcept C149034497 @default.
• W1525028622 hasConcept C150194340 @default.
• W1525028622 hasConcept C162317418 @default.
• W1525028622 hasConcept C18431079 @default.
• W1525028622 hasConcept C2775905019 @default.
• W1525028622 hasConcept C46111723 @default.
• W1525028622 hasConcept C54355233 @default.
• W1525028622 hasConcept C70721500 @default.
• W1525028622 hasConcept C86803240 @default.
• W1525028622 hasConcept C95371953 @default.
• W1525028622 hasConceptScore W1525028622C104317684 @default.
• W1525028622 hasConceptScore W1525028622C121608353 @default.
• W1525028622 hasConceptScore W1525028622C127716648 @default.
• W1525028622 hasConceptScore W1525028622C141231307 @default.
• W1525028622 hasConceptScore W1525028622C149034497 @default.
• W1525028622 hasConceptScore W1525028622C150194340 @default.
• W1525028622 hasConceptScore W1525028622C162317418 @default.
• W1525028622 hasConceptScore W1525028622C18431079 @default.
• W1525028622 hasConceptScore W1525028622C2775905019 @default.
• W1525028622 hasConceptScore W1525028622C46111723 @default.
• W1525028622 hasConceptScore W1525028622C54355233 @default.
• W1525028622 hasConceptScore W1525028622C70721500 @default.
• W1525028622 hasConceptScore W1525028622C86803240 @default.
• W1525028622 hasConceptScore W1525028622C95371953 @default.
• W1525028622 hasIssue "1" @default.
• W1525028622 hasLocation W15250286221 @default.
• W1525028622 hasLocation W15250286222 @default.
• W1525028622 hasLocation W15250286223 @default.
• W1525028622 hasLocation W15250286224 @default.
• W1525028622 hasLocation W15250286225 @default.
• W1525028622 hasLocation W15250286226 @default.
• W1525028622 hasLocation W15250286227 @default.
• W1525028622 hasLocation W15250286228 @default.
• W1525028622 hasOpenAccess W1525028622 @default.

• next