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• W1525253519 endingPage "2177" @default.
• W1525253519 startingPage "2166" @default.
• W1525253519 abstract "The Ca(2+)-binding proteins (CBPs) calbindin D28k, calretinin and parvalbumin are phenotypic markers of functionally diverse subclasses of neurons in the adult brain. The developmental dynamics of CBP expression are precisely timed: calbindin and calretinin are present in prospective cortical interneurons from mid-gestation, while parvalbumin only becomes expressed during the early postnatal period in rodents. Secretagogin (scgn) is a CBP cloned from pancreatic beta and neuroendocrine cells. We hypothesized that scgn may be expressed by particular neuronal contingents during prenatal development of the mammalian telencephalon. We find that scgn is expressed in neurons transiting in the subpallial differentiation zone by embryonic day (E)11 in mouse. From E12, scgn(+) cells commute towards the extended amygdala and colonize the bed nucleus of stria terminalis, the interstitial nucleus of the posterior limb of the anterior commissure, the dorsal substantia innominata (SI) and the central and medial amygdaloid nuclei. Scgn(+) neurons can acquire a cholinergic phenotype in the SI or differentiate into GABA cells in the central amygdala. We also uncover phylogenetic differences in scgn expression as this CBP defines not only neurons destined to the extended amygdala but also cholinergic projection cells and cortical pyramidal cells in the fetal nonhuman primate and human brains, respectively. Overall, our findings emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries." @default.
• W1525253519 created "2016-06-24" @default.
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• W1525253519 date "2010-06-01" @default.
• W1525253519 modified "2023-10-15" @default.
• W1525253519 title "Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon" @default.
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• W1525253519 doi "https://doi.org/10.1111/j.1460-9568.2010.07275.x" @default.
• W1525253519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2917754" @default.
• W1525253519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20529129" @default.
• W1525253519 hasPublicationYear "2010" @default.
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