Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525256250> ?p ?o ?g. }
- W1525256250 abstract "The lifelong generation of alpha beta T cells enables us to continuously build immunity against pathogens and malignancies despite the loss of thymic function with age. Consequently, alpha beta T-cell development has to occur independently of the thymus. However, the sites and mechanisms of extrathymic T-cell development are not yet understood in detail. gamma delta T cells represent a small fraction of the overall T-cell pool, and are endowed with tremendous phenotypic and functional plasticity. gamma delta T cells that express the Vdelta1 gene segment are a minor population in human peripheral blood but predominate in epithelial (and inflamed) tissues. Here, we characterize a peripheral Vdelta1+ gamma delta T-cell subpopulation that expresses stem-cell and progenitor markers and is able to develop into functional alpha beta T cells ex vivo in a simple culture system and in vivo. The route taken by this process resembles thymic T-cell development. However, it involves the reorganization of the Vdelta1+ gamma delta TCR into the alpha beta TCR as a consequence of TCR-gamma chain downregulation and the expression of surface Vdelta1+Vbeta+ TCR components which we believe function as surrogate pre-TCR. This transdifferentiation process is readily detectable in vivo in inflamed tissue. Our study provides a conceptual framework for extrathymic T-cell development and opens up a new vista in immunology that requires adaptive immune responses in infection, autoimmunity and cancer to be reconsidered." @default.
- W1525256250 created "2016-06-24" @default.
- W1525256250 creator A5004168451 @default.
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- W1525256250 date "2014-12-17" @default.
- W1525256250 modified "2023-10-18" @default.
- W1525256250 title "Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells" @default.
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