FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525345888> ?p ?o ?g. }

• W1525345888 endingPage "2206" @default.
• W1525345888 startingPage "2196" @default.
• W1525345888 abstract "Abstract We identified two mast cell subsets characterized by the differential expression of surface CD25 (IL-2Rα) and by different abilities to produce cytokines and to proliferate, both in vitro and in vivo. CD25 can be expressed on the surface of immune cells in the absence of the other chains of the IL-2R, which are indispensable for IL-2 signaling. We show that functional differences between the two mast cell populations were dependent on CD25 itself, which directly modulated proliferation and cytokine responses. These effects were completely independent from IL-2 or the expression of the other chains of the high-affinity IL-2R, indicating an autonomous and previously unappreciated role for CD25 in regulating cell functions. Cells genetically ablated for CD25 completely recapitulated the CD25-negative phenotype and never acquired the properties characteristic of CD25-positive mast cells. Finally, adoptive transfer experiments in the mouse demonstrated a different impact of these populations in models of anaphylaxis and contact sensitivity. Our findings indicate a general role for CD25 in contexts where IL-2 signaling is not involved, and may have important implications for all mast cell-related diseases, as well as in all cell types expressing CD25 independently of its IL-2–related functions." @default.
• W1525345888 created "2016-06-24" @default.
• W1525345888 creator A5003491885 @default.
• W1525345888 creator A5011035178 @default.
• W1525345888 creator A5020905419 @default.
• W1525345888 creator A5033195527 @default.
• W1525345888 creator A5059545456 @default.
• W1525345888 creator A5076459388 @default.
• W1525345888 creator A5080587435 @default.
• W1525345888 creator A5083376219 @default.
• W1525345888 creator A5087676128 @default.
• W1525345888 date "2014-09-01" @default.
• W1525345888 modified "2023-10-06" @default.
• W1525345888 title "Two Functionally Distinct Subsets of Mast Cells Discriminated By IL-2–Independent CD25 Activities" @default.
• W1525345888 cites W110139947 @default.
• W1525345888 cites W1571591736 @default.
• W1525345888 cites W1583735966 @default.
• W1525345888 cites W1759924756 @default.
• W1525345888 cites W1795089629 @default.
• W1525345888 cites W1833044145 @default.
• W1525345888 cites W1886304046 @default.
• W1525345888 cites W1981646849 @default.
• W1525345888 cites W1982051091 @default.
• W1525345888 cites W1982711374 @default.
• W1525345888 cites W2009232658 @default.
• W1525345888 cites W2023364946 @default.
• W1525345888 cites W2045577652 @default.
• W1525345888 cites W2051645006 @default.
• W1525345888 cites W2052998574 @default.
• W1525345888 cites W2056263350 @default.
• W1525345888 cites W2057132284 @default.
• W1525345888 cites W2058176612 @default.
• W1525345888 cites W2058289456 @default.
• W1525345888 cites W2068031380 @default.
• W1525345888 cites W2068379366 @default.
• W1525345888 cites W2071117491 @default.
• W1525345888 cites W2080236371 @default.
• W1525345888 cites W2080663614 @default.
• W1525345888 cites W2086862049 @default.
• W1525345888 cites W2095094617 @default.
• W1525345888 cites W2097065948 @default.
• W1525345888 cites W2101494714 @default.
• W1525345888 cites W2104476281 @default.
• W1525345888 cites W2107277218 @default.
• W1525345888 cites W2120816937 @default.
• W1525345888 cites W2121686426 @default.
• W1525345888 cites W2124678205 @default.
• W1525345888 cites W2138151549 @default.
• W1525345888 cites W2141458291 @default.
• W1525345888 cites W2143873035 @default.
• W1525345888 cites W2154419859 @default.
• W1525345888 cites W2170040424 @default.
• W1525345888 cites W4254229476 @default.
• W1525345888 doi "https://doi.org/10.4049/jimmunol.1400516" @default.
• W1525345888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063866" @default.
• W1525345888 hasPublicationYear "2014" @default.
• W1525345888 type Work @default.
• W1525345888 sameAs 1525345888 @default.
• W1525345888 citedByCount "13" @default.
• W1525345888 countsByYear W15253458882016 @default.
• W1525345888 countsByYear W15253458882017 @default.
• W1525345888 countsByYear W15253458882018 @default.
• W1525345888 countsByYear W15253458882020 @default.
• W1525345888 countsByYear W15253458882021 @default.
• W1525345888 countsByYear W15253458882022 @default.
• W1525345888 countsByYear W15253458882023 @default.
• W1525345888 crossrefType "journal-article" @default.
• W1525345888 hasAuthorship W1525345888A5003491885 @default.
• W1525345888 hasAuthorship W1525345888A5011035178 @default.
• W1525345888 hasAuthorship W1525345888A5020905419 @default.
• W1525345888 hasAuthorship W1525345888A5033195527 @default.
• W1525345888 hasAuthorship W1525345888A5059545456 @default.
• W1525345888 hasAuthorship W1525345888A5076459388 @default.
• W1525345888 hasAuthorship W1525345888A5080587435 @default.
• W1525345888 hasAuthorship W1525345888A5083376219 @default.
• W1525345888 hasAuthorship W1525345888A5087676128 @default.
• W1525345888 hasBestOaLocation W15253458881 @default.
• W1525345888 hasConcept C104317684 @default.
• W1525345888 hasConcept C127716648 @default.
• W1525345888 hasConcept C203014093 @default.
• W1525345888 hasConcept C2776090121 @default.
• W1525345888 hasConcept C2778690821 @default.
• W1525345888 hasConcept C2779726688 @default.
• W1525345888 hasConcept C54355233 @default.
• W1525345888 hasConcept C79484868 @default.
• W1525345888 hasConcept C86803240 @default.
• W1525345888 hasConcept C8891405 @default.
• W1525345888 hasConcept C90375314 @default.
• W1525345888 hasConcept C95444343 @default.
• W1525345888 hasConceptScore W1525345888C104317684 @default.
• W1525345888 hasConceptScore W1525345888C127716648 @default.
• W1525345888 hasConceptScore W1525345888C203014093 @default.
• W1525345888 hasConceptScore W1525345888C2776090121 @default.
• W1525345888 hasConceptScore W1525345888C2778690821 @default.
• W1525345888 hasConceptScore W1525345888C2779726688 @default.
• W1525345888 hasConceptScore W1525345888C54355233 @default.
• W1525345888 hasConceptScore W1525345888C79484868 @default.
• W1525345888 hasConceptScore W1525345888C86803240 @default.

• next