FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525348078> ?p ?o ?g. }

• W1525348078 abstract "Viruses modulate biosynthetic machineries of the host cell for a rapid and efficient virus replication. One important way of modulating protein activity in eukaryotic cells is by reversible phosphorylation. In this thesis we have studied adenovirus and vaccinia virus, two DNA viruses with different replication stategies. Adenovirus replicates and assembles new virions in the nucleus, requiring the host cell transcription and splicing machinieries, whereas vaccinia virus replicates in the cytoplasm, only requiring the cellular translation machinery for its replication. Adenovirus uses alternative RNA splicing to produce its proteins. We have shown that adenovirus takes over the cellular splicing machinery by modulating the activity of the essential cellular SR family of splicing factors. Vaccinia virus, that does not use RNA splicing, was shown to completely inactivate SR proteins as splicing regulatory factors. SR proteins are highly phosphorylated, a modification which is important for their activity as regulators of cellular pre-mRNA splicing. We have found that reversible phosphorylation of SR proteins is one mechanism to regulate alternative RNA splicing. We have demonstrated that adenovirus and vaccinia virus induce SR protein dephosphorylation, which inhibit their activity as splicing repressor and splicing activator proteins. We further showed that the adenovirus E4-ORF4 protein, which binds to the cellular protein phosphatase 2A, induced dephosphorylation of a specific SR protein, ASF/SF2, and that this mechanism was important for regulation of adenovirus alternative RNA splicing.Inhibition of cellular pre-mRNA splicing results in a block in nuclear- to cytoplasmic transport of cellular mRNAs, ensuring free access of viral mRNAs to the translation machinery. We propose that SR protein dephosphorylation may be a general viral mechanism by which mammalian viruses take control over host cell gene expression." @default.
• W1525348078 created "2016-06-24" @default.
• W1525348078 creator A5011432822 @default.
• W1525348078 date "2001-01-01" @default.
• W1525348078 modified "2023-09-27" @default.
• W1525348078 title "Viral control of SR protein activity." @default.
• W1525348078 cites W109246328 @default.
• W1525348078 cites W121402389 @default.
• W1525348078 cites W131186105 @default.
• W1525348078 cites W139324815 @default.
• W1525348078 cites W1484126091 @default.
• W1525348078 cites W1508168356 @default.
• W1525348078 cites W1508541438 @default.
• W1525348078 cites W1513114192 @default.
• W1525348078 cites W1515351996 @default.
• W1525348078 cites W1530317014 @default.
• W1525348078 cites W1531644439 @default.
• W1525348078 cites W1532420600 @default.
• W1525348078 cites W1551942931 @default.
• W1525348078 cites W1560526335 @default.
• W1525348078 cites W1595085053 @default.
• W1525348078 cites W1599357356 @default.
• W1525348078 cites W1603052159 @default.
• W1525348078 cites W1639795491 @default.
• W1525348078 cites W1643536441 @default.
• W1525348078 cites W170486316 @default.
• W1525348078 cites W1755736350 @default.
• W1525348078 cites W1790843347 @default.
• W1525348078 cites W1850691205 @default.
• W1525348078 cites W1861998732 @default.
• W1525348078 cites W1877603023 @default.
• W1525348078 cites W1888312006 @default.
• W1525348078 cites W1890830291 @default.
• W1525348078 cites W1913039750 @default.
• W1525348078 cites W1914671017 @default.
• W1525348078 cites W1915392176 @default.
• W1525348078 cites W1933950034 @default.
• W1525348078 cites W1939941461 @default.
• W1525348078 cites W1949858436 @default.
• W1525348078 cites W1953036954 @default.
• W1525348078 cites W1954151373 @default.
• W1525348078 cites W1966123525 @default.
• W1525348078 cites W1967959947 @default.
• W1525348078 cites W1968370012 @default.
• W1525348078 cites W1969097555 @default.
• W1525348078 cites W1969177542 @default.
• W1525348078 cites W1969383747 @default.
• W1525348078 cites W1971361060 @default.
• W1525348078 cites W1971385603 @default.
• W1525348078 cites W1973158635 @default.
• W1525348078 cites W1973916539 @default.
• W1525348078 cites W1975580175 @default.
• W1525348078 cites W1976967851 @default.
• W1525348078 cites W1977254598 @default.
• W1525348078 cites W1980961407 @default.
• W1525348078 cites W1982559739 @default.
• W1525348078 cites W1983225676 @default.
• W1525348078 cites W1983475354 @default.
• W1525348078 cites W1985202731 @default.
• W1525348078 cites W1985696544 @default.
• W1525348078 cites W1986486427 @default.
• W1525348078 cites W1986679685 @default.
• W1525348078 cites W1990609493 @default.
• W1525348078 cites W1992701498 @default.
• W1525348078 cites W1994313993 @default.
• W1525348078 cites W1994444072 @default.
• W1525348078 cites W1996347498 @default.
• W1525348078 cites W1998113157 @default.
• W1525348078 cites W1999037332 @default.
• W1525348078 cites W1999690952 @default.
• W1525348078 cites W1999758935 @default.
• W1525348078 cites W2003558241 @default.
• W1525348078 cites W2003757297 @default.
• W1525348078 cites W2004509913 @default.
• W1525348078 cites W2005052610 @default.
• W1525348078 cites W2005100774 @default.
• W1525348078 cites W2007164277 @default.
• W1525348078 cites W2008374272 @default.
• W1525348078 cites W2008467118 @default.
• W1525348078 cites W2011625250 @default.
• W1525348078 cites W2012736092 @default.
• W1525348078 cites W2013002081 @default.
• W1525348078 cites W2013955971 @default.
• W1525348078 cites W2014427312 @default.
• W1525348078 cites W2014791263 @default.
• W1525348078 cites W2015775176 @default.
• W1525348078 cites W2020195610 @default.
• W1525348078 cites W2022276118 @default.
• W1525348078 cites W2022734399 @default.
• W1525348078 cites W2023199595 @default.
• W1525348078 cites W2023418239 @default.
• W1525348078 cites W2023542289 @default.
• W1525348078 cites W2024141550 @default.
• W1525348078 cites W2025607175 @default.
• W1525348078 cites W2026923004 @default.
• W1525348078 cites W2027699344 @default.
• W1525348078 cites W2029047331 @default.
• W1525348078 cites W2030375968 @default.
• W1525348078 cites W2030932054 @default.
• W1525348078 cites W2031214064 @default.

• next