FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525486670> ?p ?o ?g. }

• W1525486670 abstract "p15INK4b expression is lost in a striking 80% of all patients suffering from acute myeloid leukemia (AML). Specific inactivation of the gene by aberrant promoter hypermethylation is also detected in about 50% of patients diagnosed with myelodysplastic syndromes (MDS) and almost 60% of patients with myeloproliferative disorders (MPD). More importantly, a strong correlation between the methylation levels of p15INK4b and poor prognosis is now well established in these patients. Hypermethylation levels also provide a marker for subsequent transformation and progression of the disease to a more aggressive phenotype. These clinical observations establish the repression of p15INK4b expression by promoter hypermethylation as the most prevalent genetic abnormality in myeloid leukemia. The p15INK4b gene (also referred to as CDKN2B and MTS2) encodes a 15kDa cyclin dependent kinase inhibitor (CDKI). Specific and preferential epigenetic targeting of p15INK4b for silencing over other CDKIs such as p16INK4a and p21WAF/CIP in AML, MDS and MPD patients strongly supports a role for this protein as a tumor suppressor in hematological malignancies of the myeloid lineage. This chapter provides a review of the literature outlining the high prevalence of p15INK4b loss of expression in human myeloid malignancies, as well as the latest research carried out in mice which supports a role for p15Ink4b as a tumor suppressor. It also focuses on the well established function of p15INK4b in the control of the cell cycle, as well as its role during early and late myeloid cells development. Finally, this chapter discusses the multiple mechanisms by which p15INK4b is silenced and presents a few examples of clinical studies of drugs that target p15INK4b for re-expression. These include treatments for reversing aberrant DNA methylation, and are currently being tested and used for the therapy of MDS and AML." @default.
• W1525486670 created "2016-06-24" @default.
• W1525486670 creator A5030577323 @default.
• W1525486670 creator A5057494470 @default.
• W1525486670 creator A5082376287 @default.
• W1525486670 date "2011-12-14" @default.
• W1525486670 modified "2023-09-25" @default.
• W1525486670 title "p15INK4b, a Tumor Suppressor in Acute Myeloid Leukemia" @default.
• W1525486670 cites W1492452294 @default.
• W1525486670 cites W1504303645 @default.
• W1525486670 cites W1516326873 @default.
• W1525486670 cites W1525531613 @default.
• W1525486670 cites W1549705622 @default.
• W1525486670 cites W1573155301 @default.
• W1525486670 cites W1585309559 @default.
• W1525486670 cites W1595293335 @default.
• W1525486670 cites W1622452956 @default.
• W1525486670 cites W1661110056 @default.
• W1525486670 cites W1670953131 @default.
• W1525486670 cites W191043282 @default.
• W1525486670 cites W1964769402 @default.
• W1525486670 cites W1965809040 @default.
• W1525486670 cites W1973677698 @default.
• W1525486670 cites W1974079495 @default.
• W1525486670 cites W1975268103 @default.
• W1525486670 cites W1975924585 @default.
• W1525486670 cites W1980195124 @default.
• W1525486670 cites W1980484736 @default.
• W1525486670 cites W1983365671 @default.
• W1525486670 cites W1986069316 @default.
• W1525486670 cites W1986763150 @default.
• W1525486670 cites W1989168159 @default.
• W1525486670 cites W1990763586 @default.
• W1525486670 cites W1991858306 @default.
• W1525486670 cites W1992254726 @default.
• W1525486670 cites W1992861793 @default.
• W1525486670 cites W1996919750 @default.
• W1525486670 cites W1997073961 @default.
• W1525486670 cites W1997439197 @default.
• W1525486670 cites W1997805699 @default.
• W1525486670 cites W1999698703 @default.
• W1525486670 cites W2001480633 @default.
• W1525486670 cites W2003223749 @default.
• W1525486670 cites W2003476399 @default.
• W1525486670 cites W2003907692 @default.
• W1525486670 cites W2006354293 @default.
• W1525486670 cites W2008731424 @default.
• W1525486670 cites W2009178790 @default.
• W1525486670 cites W2012782052 @default.
• W1525486670 cites W2014462533 @default.
• W1525486670 cites W2021458995 @default.
• W1525486670 cites W2022733644 @default.
• W1525486670 cites W2028319593 @default.
• W1525486670 cites W2035572566 @default.
• W1525486670 cites W2042342722 @default.
• W1525486670 cites W2046517084 @default.
• W1525486670 cites W2049085719 @default.
• W1525486670 cites W2054616973 @default.
• W1525486670 cites W2054759945 @default.
• W1525486670 cites W2058383883 @default.
• W1525486670 cites W2059176522 @default.
• W1525486670 cites W2059557201 @default.
• W1525486670 cites W2062145659 @default.
• W1525486670 cites W2062375341 @default.
• W1525486670 cites W2069091539 @default.
• W1525486670 cites W2071427066 @default.
• W1525486670 cites W2075731214 @default.
• W1525486670 cites W2076426515 @default.
• W1525486670 cites W2077836004 @default.
• W1525486670 cites W2079190650 @default.
• W1525486670 cites W2079651105 @default.
• W1525486670 cites W2080613123 @default.
• W1525486670 cites W2084630860 @default.
• W1525486670 cites W2088633051 @default.
• W1525486670 cites W2088827126 @default.
• W1525486670 cites W2090178269 @default.
• W1525486670 cites W2090786449 @default.
• W1525486670 cites W2091897357 @default.
• W1525486670 cites W2093845572 @default.
• W1525486670 cites W2096632866 @default.
• W1525486670 cites W2096638244 @default.
• W1525486670 cites W2097146973 @default.
• W1525486670 cites W2097160518 @default.
• W1525486670 cites W2099343472 @default.
• W1525486670 cites W2113032193 @default.
• W1525486670 cites W2115858100 @default.
• W1525486670 cites W2117291755 @default.
• W1525486670 cites W2120091268 @default.
• W1525486670 cites W2121417064 @default.
• W1525486670 cites W2121619780 @default.
• W1525486670 cites W2127240439 @default.
• W1525486670 cites W2127614473 @default.
• W1525486670 cites W2134775408 @default.
• W1525486670 cites W2139017293 @default.
• W1525486670 cites W2139771648 @default.
• W1525486670 cites W2141566331 @default.
• W1525486670 cites W2143658931 @default.
• W1525486670 cites W2144028808 @default.
• W1525486670 cites W2150113701 @default.
• W1525486670 cites W2152534875 @default.

• next