FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525488085> ?p ?o ?g. }

• W1525488085 endingPage "IN12" @default.
• W1525488085 startingPage "196" @default.
• W1525488085 abstract "Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players. Transcriptional control of uPAR expression by HIF has never been reported. The aim of the present study, therefore, was to test whether tumor hypoxia-induced HIF expression may be linked to transcriptional activation of uPAR and dependent angioinvasion. We used human pancreatic cancer cells and a model of parental and derived HIF-1β-deficient mouse liver cancer cell lines and performed Northern blot analysis, nuclear runoff assays, electrophoretic mobility shift assay, polymerase chain reaction-generated deletion mutants, luciferase assays, Matrigel invasion assays, and in vivo angioinvasion assays in the chorioallantoic membrane of fertilized chicken eggs. Urokinase-type plasminogen activator receptor promoter analysis resulted in four putative HIF binding sites. Hypoxia strongly induced de novo transcription of uPAR mRNA. With sequential deletion mutants of the uPAR promoter, it was possible to identify one HIF binding site causing a nearly 200-fold increase in luciferase activity. Hypoxia enhanced the number of invading tumor cells in vitro and in vivo. In contrast, HIF-1β-deficient cells failed to upregulate uPAR expression, to activate luciferase activity, and to invade on hypoxia. Taken together, we show for the first time that uPAR is under transcriptional control of HIF and that this is important for hypoxia-induced metastasis." @default.
• W1525488085 created "2016-06-24" @default.
• W1525488085 creator A5011338620 @default.
• W1525488085 creator A5019576697 @default.
• W1525488085 creator A5040670439 @default.
• W1525488085 creator A5047089607 @default.
• W1525488085 creator A5069362975 @default.
• W1525488085 creator A5087750803 @default.
• W1525488085 creator A5089608755 @default.
• W1525488085 creator A5091265792 @default.
• W1525488085 date "2009-02-01" @default.
• W1525488085 modified "2023-10-13" @default.
• W1525488085 title "Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer" @default.
• W1525488085 cites W10381981 @default.
• W1525488085 cites W1516591589 @default.
• W1525488085 cites W1518750032 @default.
• W1525488085 cites W1567112601 @default.
• W1525488085 cites W1749022239 @default.
• W1525488085 cites W181093158 @default.
• W1525488085 cites W1921426554 @default.
• W1525488085 cites W1953156003 @default.
• W1525488085 cites W1968087152 @default.
• W1525488085 cites W1972779778 @default.
• W1525488085 cites W1978598058 @default.
• W1525488085 cites W1979129905 @default.
• W1525488085 cites W1979196564 @default.
• W1525488085 cites W1980214543 @default.
• W1525488085 cites W1980741832 @default.
• W1525488085 cites W1982265633 @default.
• W1525488085 cites W1983075687 @default.
• W1525488085 cites W1985204470 @default.
• W1525488085 cites W1991843895 @default.
• W1525488085 cites W1999334756 @default.
• W1525488085 cites W2003593894 @default.
• W1525488085 cites W2005942661 @default.
• W1525488085 cites W2010356452 @default.
• W1525488085 cites W2010394923 @default.
• W1525488085 cites W2011810742 @default.
• W1525488085 cites W2011816149 @default.
• W1525488085 cites W2020820485 @default.
• W1525488085 cites W2028999918 @default.
• W1525488085 cites W2033623967 @default.
• W1525488085 cites W2038750685 @default.
• W1525488085 cites W2040031153 @default.
• W1525488085 cites W2041211828 @default.
• W1525488085 cites W2045072818 @default.
• W1525488085 cites W2045155219 @default.
• W1525488085 cites W2047039315 @default.
• W1525488085 cites W2054987125 @default.
• W1525488085 cites W2061050659 @default.
• W1525488085 cites W2065642253 @default.
• W1525488085 cites W2066616614 @default.
• W1525488085 cites W2070385942 @default.
• W1525488085 cites W2074061934 @default.
• W1525488085 cites W2079718648 @default.
• W1525488085 cites W2082483448 @default.
• W1525488085 cites W2085609942 @default.
• W1525488085 cites W2092565468 @default.
• W1525488085 cites W2111983416 @default.
• W1525488085 cites W2115947409 @default.
• W1525488085 cites W2124064466 @default.
• W1525488085 cites W2124496728 @default.
• W1525488085 cites W2125257427 @default.
• W1525488085 cites W2136826625 @default.
• W1525488085 cites W2140496726 @default.
• W1525488085 cites W2144625075 @default.
• W1525488085 cites W2145208368 @default.
• W1525488085 cites W2146097802 @default.
• W1525488085 cites W2152326461 @default.
• W1525488085 cites W4213141530 @default.
• W1525488085 cites W4324263428 @default.
• W1525488085 doi "https://doi.org/10.1593/neo.08734" @default.
• W1525488085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2631144" @default.
• W1525488085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19177204" @default.
• W1525488085 hasPublicationYear "2009" @default.
• W1525488085 type Work @default.
• W1525488085 sameAs 1525488085 @default.
• W1525488085 citedByCount "65" @default.
• W1525488085 countsByYear W15254880852012 @default.
• W1525488085 countsByYear W15254880852013 @default.
• W1525488085 countsByYear W15254880852014 @default.
• W1525488085 countsByYear W15254880852015 @default.
• W1525488085 countsByYear W15254880852016 @default.
• W1525488085 countsByYear W15254880852017 @default.
• W1525488085 countsByYear W15254880852018 @default.
• W1525488085 countsByYear W15254880852020 @default.
• W1525488085 countsByYear W15254880852021 @default.
• W1525488085 countsByYear W15254880852022 @default.
• W1525488085 countsByYear W15254880852023 @default.
• W1525488085 crossrefType "journal-article" @default.
• W1525488085 hasAuthorship W1525488085A5011338620 @default.
• W1525488085 hasAuthorship W1525488085A5019576697 @default.
• W1525488085 hasAuthorship W1525488085A5040670439 @default.
• W1525488085 hasAuthorship W1525488085A5047089607 @default.
• W1525488085 hasAuthorship W1525488085A5069362975 @default.
• W1525488085 hasAuthorship W1525488085A5087750803 @default.
• W1525488085 hasAuthorship W1525488085A5089608755 @default.
• W1525488085 hasAuthorship W1525488085A5091265792 @default.

• next