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• W1525589992 abstract "1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concentration. 3 In spite of the increase in unbound fraction, both the total and free serum concentrations of phenytoin were decreased in late pregnancy." @default.
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• W1525589992 date "1982-04-01" @default.
• W1525589992 modified "2023-10-12" @default.
• W1525589992 title "Serum protein binding and free concentration of phenytoin and phenobarbitone in pregnancy." @default.
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• W1525589992 doi "https://doi.org/10.1111/j.1365-2125.1982.tb01420.x" @default.
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