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• W1525592915 startingPage "341" @default.
• W1525592915 abstract "In this chapter the modulatory roles of corticosteroid hormones in motivated behaviours are reviewed. On the one side, motivation is considered as a complex construct central to adaptive behaviours and related to cognition and emotion. On the other side, these hormones act upon many brain regions through glucocorticoid and mineralocorticoid receptors. These central actions have been shown to participate in the regulatory processes leading to adaptation. Pathologies of the adrenal gland provide insights into the role of these hormones, in general. Both in Addison’s disease and Cushing’s syndrome many symptoms relate on motivational–emotional deficits. Examples will be provided that evidence a role of glucocorticoids on reinforcement processes. These hormones act on the reward system and are thought to facilitate dopamine utilization. Through a direct reward process, the hormones, like drugs of abuse, are self-administered orally or intravenously. Some individuals are vulnerable to drug and characterized by an increase in dopamine utilization in the mesocorticolimbic system during environmental challenges and are prone to self-administer the hormone and drug of abuse. It will be shown that the stress hormones participate in pathophysiological processes making the organism more vulnerable to various pathologies." @default.
• W1525592915 created "2016-06-24" @default.
• W1525592915 creator A5046905337 @default.
• W1525592915 creator A5071362325 @default.
• W1525592915 creator A5089086821 @default.
• W1525592915 date "2005-01-01" @default.
• W1525592915 modified "2023-10-18" @default.
• W1525592915 title "Glucocorticoids and motivated behaviour" @default.
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