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- W1525607292 abstract "A sensitive instrument has been constructed to measure the development and subsequent relaxation of the isometric tension during the heating of collagenous tissues. The curves of the tension developed by rat skin plotted against temperature exhibited different shapes according to the age of the animal. In skin from new born rats the maintenance of the maximum tension up to temperatures around 95°C appeared to be correlated with the presence of the thermally stable “keto” cross-link. In adult skin the dramatic relaxation of the tension that occurred above 75°C correlated with the increased proportion of the heat labile “aldimine” cross-link. With increasing age the extent of this relaxation decreased due to the increasing proportion of thermally stable cross-links of unknown origin. The curves obtained with granulation tissues of acute inflammation during the development phase and subsequent resorption phase of the granuloma were similar to those obtained during the growth of young animals from birth to 1 month. On the other hand granulation tissues of chronic inflammation retained an isometric tension curve similar to that of the new born rat skin, even after a long period of inflammation (8 months). Determination of the isometric tension developed in heated tissues provides a rapid assay useful for obtaining preliminary information on the cross-linking of collagen fibres in normal and pathological situations." @default.
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- W1525607292 date "1978-03-01" @default.
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- W1525607292 title "Isometric tension developed during heating of collagenous tissues" @default.
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- W1525607292 doi "https://doi.org/10.1016/0005-2795(78)90558-5" @default.
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