Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525625571> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1525625571 endingPage "143" @default.
- W1525625571 startingPage "135" @default.
- W1525625571 abstract "Insulin-like growth factor I (IGF-I) accumulates in the kidney following the onset of diabetes, initiating diabetic renal hypertrophy. Increased renal IGF-I protein content, which is not reflected in messenger RNA (mRNA) levels, suggests that renal IGF-I accumulation is due to sequestration of circulating IGF-I rather than to local synthesis. It has been suggested that IGF-I is trapped in the kidney by IGF binding protein 1 (IGFBP-1). We administered purified human IGFBP-1 (hIGFBP-1) to nondiabetic and diabetic mice as three daily sc injections for 14 days, starting 6 days after induction of streptozotocin diabetes when the animals were overtly diabetic. Markers of early diabetic renal changes (i.e., increased kidney weight, glomerular volume, and albuminuria) coincided with accumulation of renal cortical IGF-I despite decreased mRNA levels in 20-day diabetic mice. Human IGFBP-1 administration had no effect on increased kidney weight or albuminuria in early diabetes, although it abolished renal cortical IGF-I accumulation and glomerular hypertrophy in diabetic mice. Increased IGF-I levels in kidneys of normal mice receiving hIGFBP-1 were not reflected on kidney parameters. IGFBP-1 administration in diabetic mice had only minor effects on diabetic renal changes. Accordingly, these results did not support the hypothesis that IGFBP-1 plays a major role in early renal changes in diabetes." @default.
- W1525625571 created "2016-06-24" @default.
- W1525625571 creator A5002371087 @default.
- W1525625571 creator A5019251610 @default.
- W1525625571 creator A5021103060 @default.
- W1525625571 creator A5029397568 @default.
- W1525625571 creator A5040063505 @default.
- W1525625571 creator A5041201756 @default.
- W1525625571 creator A5057379773 @default.
- W1525625571 date "2005-02-01" @default.
- W1525625571 modified "2023-09-27" @default.
- W1525625571 title "Kidney Growth in Normal and Diabetic Mice is not Affected by Human Insulin-Like Growth Factor Binding Protein-1 Administration" @default.
- W1525625571 cites W168969388 @default.
- W1525625571 cites W2004307717 @default.
- W1525625571 cites W2012505775 @default.
- W1525625571 cites W2014806222 @default.
- W1525625571 cites W2020511056 @default.
- W1525625571 cites W2021005975 @default.
- W1525625571 cites W2044943066 @default.
- W1525625571 cites W2047059589 @default.
- W1525625571 cites W2051257362 @default.
- W1525625571 cites W2068470146 @default.
- W1525625571 cites W2090099477 @default.
- W1525625571 cites W2098742882 @default.
- W1525625571 cites W2102303758 @default.
- W1525625571 cites W2107714446 @default.
- W1525625571 cites W2125508002 @default.
- W1525625571 cites W2142531099 @default.
- W1525625571 cites W2143269563 @default.
- W1525625571 cites W2168279537 @default.
- W1525625571 cites W2169683011 @default.
- W1525625571 cites W2248149147 @default.
- W1525625571 doi "https://doi.org/10.1177/153537020523000208" @default.
- W1525625571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15673562" @default.
- W1525625571 hasPublicationYear "2005" @default.
- W1525625571 type Work @default.
- W1525625571 sameAs 1525625571 @default.
- W1525625571 citedByCount "7" @default.
- W1525625571 countsByYear W15256255712015 @default.
- W1525625571 countsByYear W15256255712019 @default.
- W1525625571 countsByYear W15256255712021 @default.
- W1525625571 crossrefType "journal-article" @default.
- W1525625571 hasAuthorship W1525625571A5002371087 @default.
- W1525625571 hasAuthorship W1525625571A5019251610 @default.
- W1525625571 hasAuthorship W1525625571A5021103060 @default.
- W1525625571 hasAuthorship W1525625571A5029397568 @default.
- W1525625571 hasAuthorship W1525625571A5040063505 @default.
- W1525625571 hasAuthorship W1525625571A5041201756 @default.
- W1525625571 hasAuthorship W1525625571A5057379773 @default.
- W1525625571 hasBestOaLocation W15256255712 @default.
- W1525625571 hasConcept C126322002 @default.
- W1525625571 hasConcept C134018914 @default.
- W1525625571 hasConcept C167414201 @default.
- W1525625571 hasConcept C170493617 @default.
- W1525625571 hasConcept C2775960820 @default.
- W1525625571 hasConcept C2776174234 @default.
- W1525625571 hasConcept C2779280383 @default.
- W1525625571 hasConcept C2779922275 @default.
- W1525625571 hasConcept C2780091579 @default.
- W1525625571 hasConcept C2909763481 @default.
- W1525625571 hasConcept C555293320 @default.
- W1525625571 hasConcept C71924100 @default.
- W1525625571 hasConceptScore W1525625571C126322002 @default.
- W1525625571 hasConceptScore W1525625571C134018914 @default.
- W1525625571 hasConceptScore W1525625571C167414201 @default.
- W1525625571 hasConceptScore W1525625571C170493617 @default.
- W1525625571 hasConceptScore W1525625571C2775960820 @default.
- W1525625571 hasConceptScore W1525625571C2776174234 @default.
- W1525625571 hasConceptScore W1525625571C2779280383 @default.
- W1525625571 hasConceptScore W1525625571C2779922275 @default.
- W1525625571 hasConceptScore W1525625571C2780091579 @default.
- W1525625571 hasConceptScore W1525625571C2909763481 @default.
- W1525625571 hasConceptScore W1525625571C555293320 @default.
- W1525625571 hasConceptScore W1525625571C71924100 @default.
- W1525625571 hasIssue "2" @default.
- W1525625571 hasLocation W15256255711 @default.
- W1525625571 hasLocation W15256255712 @default.
- W1525625571 hasLocation W15256255713 @default.
- W1525625571 hasLocation W15256255714 @default.
- W1525625571 hasOpenAccess W1525625571 @default.
- W1525625571 hasPrimaryLocation W15256255711 @default.
- W1525625571 hasRelatedWork W2032111989 @default.
- W1525625571 hasRelatedWork W2042033030 @default.
- W1525625571 hasRelatedWork W2044943066 @default.
- W1525625571 hasRelatedWork W2070511355 @default.
- W1525625571 hasRelatedWork W2077747914 @default.
- W1525625571 hasRelatedWork W2096973883 @default.
- W1525625571 hasRelatedWork W2126063009 @default.
- W1525625571 hasRelatedWork W2127085070 @default.
- W1525625571 hasRelatedWork W2144447642 @default.
- W1525625571 hasRelatedWork W2400445066 @default.
- W1525625571 hasVolume "230" @default.
- W1525625571 isParatext "false" @default.
- W1525625571 isRetracted "false" @default.
- W1525625571 magId "1525625571" @default.
- W1525625571 workType "article" @default.