FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525628723> ?p ?o ?g. }

• W1525628723 endingPage "12711" @default.
• W1525628723 startingPage "12699" @default.
• W1525628723 abstract "The proteoglycan decorin modulates leukocyte recruitment during delayed-type hypersensitivity responses. Decorin-deficient (Dcn(-/-)) mice show reduced edema formation during the first 24 h with a concurrent attenuated recruitment of CD8(+) leukocytes in the inflamed Dcn(-/-) ears. The aim of this study was to elucidate the molecular pathways affected by the loss of decorin. In vivo, reduced numbers of CD8(+) cells in Dcn(-/-) ears correlated with a reduced interferon-γ (Ifn-γ) and CXCL-10 expression. In vitro, Dcn(-/-) lymphocytes displayed an increased adhesion to brain microvascular (bEnd.3) endothelial cells. Decorin treatment of bEnd.3 increased Icam1 and down-regulated Vcam1 expression after TNF-α stimulation. However, Dcn(-/-) and wild-type lymphocytes produced IFN-γ after activation with CD3ε. Upon incubation with decorin, endothelial cells and fibroblasts responded differently to IFN-γ and TNF-α; CCL2 in bEnd.3 cells was more prominently up-regulated by TNF-α compared with IFN-γ. Notably, both factors were more potent in the presence of decorin. Compared with TNF-α, IFN-γ treatment induced significantly more CXCL-10, and both factors increased synthesis of CXCL-10 in the presence of decorin. The response to IFN-γ was similar in Dcn(-/-) and wild-type fibroblasts, an additional source of CXCL-10. However, addition of decorin yielded significantly more CXCL-10. Notably, decorin increased the stability of IFN-γ in vitro and potentiated IFN-γ-induced activation of STAT-1. Furthermore, only dermatan sulfate influenced IFN-γ signaling by significantly increasing CXCL-10 expression in contrast to decorin protein core alone. Our data demonstrate that decorin modulates delayed-type hypersensitivity responses by augmenting the induction of downstream effector cytokines of IFN-γ and TNF-α, thereby influencing the recruitment of CD8(+) lymphocytes into the inflamed tissue." @default.
• W1525628723 created "2016-06-24" @default.
• W1525628723 creator A5017550373 @default.
• W1525628723 creator A5030553564 @default.
• W1525628723 creator A5033789891 @default.
• W1525628723 creator A5034776080 @default.
• W1525628723 creator A5061765255 @default.
• W1525628723 creator A5066366078 @default.
• W1525628723 date "2013-05-01" @default.
• W1525628723 modified "2023-10-07" @default.
• W1525628723 title "Decorin Potentiates Interferon-γ Activity in a Model of Allergic Inflammation" @default.
• W1525628723 cites W1495596401 @default.
• W1525628723 cites W1497186327 @default.
• W1525628723 cites W1524870232 @default.
• W1525628723 cites W1526364313 @default.
• W1525628723 cites W1546862476 @default.
• W1525628723 cites W1587979699 @default.
• W1525628723 cites W1604401260 @default.
• W1525628723 cites W1647872447 @default.
• W1525628723 cites W1917712557 @default.
• W1525628723 cites W1965979066 @default.
• W1525628723 cites W1971246306 @default.
• W1525628723 cites W1972044159 @default.
• W1525628723 cites W1972789666 @default.
• W1525628723 cites W1974005261 @default.
• W1525628723 cites W1979793842 @default.
• W1525628723 cites W1982805461 @default.
• W1525628723 cites W1984743811 @default.
• W1525628723 cites W1987383242 @default.
• W1525628723 cites W1993751346 @default.
• W1525628723 cites W1994334062 @default.
• W1525628723 cites W2001244523 @default.
• W1525628723 cites W2010663570 @default.
• W1525628723 cites W2012511365 @default.
• W1525628723 cites W2016005410 @default.
• W1525628723 cites W2019587275 @default.
• W1525628723 cites W2020280540 @default.
• W1525628723 cites W2027912655 @default.
• W1525628723 cites W2027994069 @default.
• W1525628723 cites W2028514452 @default.
• W1525628723 cites W2033321756 @default.
• W1525628723 cites W2035640198 @default.
• W1525628723 cites W2038092385 @default.
• W1525628723 cites W2049482600 @default.
• W1525628723 cites W2060944699 @default.
• W1525628723 cites W2062748380 @default.
• W1525628723 cites W2067507231 @default.
• W1525628723 cites W2070013317 @default.
• W1525628723 cites W2070296847 @default.
• W1525628723 cites W2072195899 @default.
• W1525628723 cites W2073860634 @default.
• W1525628723 cites W2077361460 @default.
• W1525628723 cites W2081379713 @default.
• W1525628723 cites W2084084372 @default.
• W1525628723 cites W2088193529 @default.
• W1525628723 cites W2092894443 @default.
• W1525628723 cites W2094242637 @default.
• W1525628723 cites W2102070721 @default.
• W1525628723 cites W2107277218 @default.
• W1525628723 cites W2108830789 @default.
• W1525628723 cites W2116658756 @default.
• W1525628723 cites W2117626573 @default.
• W1525628723 cites W2122940411 @default.
• W1525628723 cites W2129071472 @default.
• W1525628723 cites W2131966577 @default.
• W1525628723 cites W2132312460 @default.
• W1525628723 cites W2138290228 @default.
• W1525628723 cites W2149357527 @default.
• W1525628723 cites W2154437417 @default.
• W1525628723 cites W2157698060 @default.
• W1525628723 cites W2162192690 @default.
• W1525628723 cites W2172216752 @default.
• W1525628723 cites W4250801983 @default.
• W1525628723 doi "https://doi.org/10.1074/jbc.m112.419366" @default.
• W1525628723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3642316" @default.
• W1525628723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23460644" @default.
• W1525628723 hasPublicationYear "2013" @default.
• W1525628723 type Work @default.
• W1525628723 sameAs 1525628723 @default.
• W1525628723 citedByCount "28" @default.
• W1525628723 countsByYear W15256287232014 @default.
• W1525628723 countsByYear W15256287232015 @default.
• W1525628723 countsByYear W15256287232016 @default.
• W1525628723 countsByYear W15256287232017 @default.
• W1525628723 countsByYear W15256287232018 @default.
• W1525628723 countsByYear W15256287232019 @default.
• W1525628723 countsByYear W15256287232020 @default.
• W1525628723 countsByYear W15256287232021 @default.
• W1525628723 countsByYear W15256287232022 @default.
• W1525628723 countsByYear W15256287232023 @default.
• W1525628723 crossrefType "journal-article" @default.
• W1525628723 hasAuthorship W1525628723A5017550373 @default.
• W1525628723 hasAuthorship W1525628723A5030553564 @default.
• W1525628723 hasAuthorship W1525628723A5033789891 @default.
• W1525628723 hasAuthorship W1525628723A5034776080 @default.
• W1525628723 hasAuthorship W1525628723A5061765255 @default.
• W1525628723 hasAuthorship W1525628723A5066366078 @default.
• W1525628723 hasBestOaLocation W15256287231 @default.

• next