FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1525662809> ?p ?o ?g. }

• W1525662809 endingPage "255" @default.
• W1525662809 startingPage "243" @default.
• W1525662809 abstract "This chapter discusses various sources of oxygen radicals and antioxidant defenses in the airways, and the role of the oxidant-sensitive transcription factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and its downstream targets on airway epithelial function. Reactive oxygen species (ROS) in airways may originate from endogenous and/or exogenous sources. Endogenous sources include respiratory bursts from activated inflammatory and immune cells, normal metabolic reactions with the electron transport chain of the mitochondria being the major source and resident airway epithelial cells themselves. Exogenous sources of ROS include exposure to environmental air pollutants, ozone and cigarette smoke. Cigarette smoke, an extremely rich source of oxidants, elicits proinflammatory response in the airways via NF-κB activation, and resultant cytokine production and release. In the airways, systemic inflammatory responses, such as sepsis, severe trauma, and burns, as well as many noxious and/or inflammatory stimuli including bacterial products and ozone, have been known to activate the transcription factor, NF-κB. In quiescent cells, NF-κB is sequestered to the cytosplasm in an inhibitory complex with inhibitor of kappa B (IκB). Following cellular stimulation, IκB molecules become phosphorylated at several serine residues in the amino terminus by IκB kinase 2 (IKK2), which targets them for ubiquitination and proteosome-degradation. This process allows nuclear translocation of NF- κB for transcriptional activation of a variety of pro-inflammatory genes." @default.
• W1525662809 created "2016-06-24" @default.
• W1525662809 creator A5038240976 @default.
• W1525662809 creator A5081860028 @default.
• W1525662809 date "2008-01-01" @default.
• W1525662809 modified "2023-09-27" @default.
• W1525662809 title "Chapter 11 Oxidant Stress and Airway Epithelial Function" @default.
• W1525662809 cites W106062352 @default.
• W1525662809 cites W1507082667 @default.
• W1525662809 cites W1518302436 @default.
• W1525662809 cites W1546629881 @default.
• W1525662809 cites W1764482514 @default.
• W1525662809 cites W1797875963 @default.
• W1525662809 cites W1822904756 @default.
• W1525662809 cites W1966032012 @default.
• W1525662809 cites W1967468829 @default.
• W1525662809 cites W1968051764 @default.
• W1525662809 cites W1972545081 @default.
• W1525662809 cites W1980090150 @default.
• W1525662809 cites W1982724662 @default.
• W1525662809 cites W1983754228 @default.
• W1525662809 cites W1984454286 @default.
• W1525662809 cites W1986993954 @default.
• W1525662809 cites W1990886575 @default.
• W1525662809 cites W1992673961 @default.
• W1525662809 cites W1997303343 @default.
• W1525662809 cites W2001461099 @default.
• W1525662809 cites W2003115733 @default.
• W1525662809 cites W2004756503 @default.
• W1525662809 cites W2014004590 @default.
• W1525662809 cites W2019163543 @default.
• W1525662809 cites W2019354571 @default.
• W1525662809 cites W2020804905 @default.
• W1525662809 cites W2021583977 @default.
• W1525662809 cites W2026597192 @default.
• W1525662809 cites W2027632610 @default.
• W1525662809 cites W2030106405 @default.
• W1525662809 cites W2036614649 @default.
• W1525662809 cites W2036921691 @default.
• W1525662809 cites W2037666231 @default.
• W1525662809 cites W2041550275 @default.
• W1525662809 cites W2048563316 @default.
• W1525662809 cites W2051654757 @default.
• W1525662809 cites W2055244730 @default.
• W1525662809 cites W2058821788 @default.
• W1525662809 cites W2058962861 @default.
• W1525662809 cites W2059232582 @default.
• W1525662809 cites W2071051432 @default.
• W1525662809 cites W2072376737 @default.
• W1525662809 cites W2075211725 @default.
• W1525662809 cites W2077847842 @default.
• W1525662809 cites W2081934986 @default.
• W1525662809 cites W2085930906 @default.
• W1525662809 cites W2087975984 @default.
• W1525662809 cites W2093680901 @default.
• W1525662809 cites W2094655287 @default.
• W1525662809 cites W2095693670 @default.
• W1525662809 cites W2098710866 @default.
• W1525662809 cites W2103219684 @default.
• W1525662809 cites W2104881442 @default.
• W1525662809 cites W2104928971 @default.
• W1525662809 cites W2111132370 @default.
• W1525662809 cites W2114624864 @default.
• W1525662809 cites W2118755647 @default.
• W1525662809 cites W2119621267 @default.
• W1525662809 cites W2120050789 @default.
• W1525662809 cites W2120659958 @default.
• W1525662809 cites W2121467769 @default.
• W1525662809 cites W2127748163 @default.
• W1525662809 cites W2128370442 @default.
• W1525662809 cites W2129853879 @default.
• W1525662809 cites W2131662651 @default.
• W1525662809 cites W2131944279 @default.
• W1525662809 cites W2132446717 @default.
• W1525662809 cites W2135323720 @default.
• W1525662809 cites W2140854669 @default.
• W1525662809 cites W2140914037 @default.
• W1525662809 cites W2146240100 @default.
• W1525662809 cites W2147275506 @default.
• W1525662809 cites W2147921405 @default.
• W1525662809 cites W2152520891 @default.
• W1525662809 cites W2154563160 @default.
• W1525662809 cites W2156761725 @default.
• W1525662809 cites W2162010936 @default.
• W1525662809 cites W2163411441 @default.
• W1525662809 cites W2171103867 @default.
• W1525662809 cites W2204123985 @default.
• W1525662809 cites W2337512367 @default.
• W1525662809 cites W2395758000 @default.
• W1525662809 cites W2405138310 @default.
• W1525662809 cites W2591757326 @default.
• W1525662809 cites W3106798016 @default.
• W1525662809 cites W3143776549 @default.
• W1525662809 cites W599936820 @default.
• W1525662809 cites W2038890616 @default.
• W1525662809 doi "https://doi.org/10.1016/s1063-5823(08)00211-1" @default.
• W1525662809 hasPublicationYear "2008" @default.
• W1525662809 type Work @default.

• next