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- W1525702986 abstract "Abstract Foxp3+ regulatory T cells (Treg) are critical for the maintenance of immunological tolerance, and a mutation of the Foxp3 gene leads to the absence of Treg and a fatal systemic autoimmune disease in Scurfy mice. Transfer of Scurfy lymphocytes to RAG-/- recipients reproduces the inflammatory phenotype of the Scurfy donor including hepatitis and pneumonitis. Here, we show that TCRα-/- recipients, that lack TCRαβ+ T cells, but have TCRγδ+ T cells and B cells, are significantly protected from autoimmunity induced by adoptive transfer of Scurfy lymphocytes. Co-transfer of Scurfy lymphocytes and B cells from TCRα-/- mice into RAG-/- recipients failed to prevent inflammation. Furthermore, transfer of Scurfy lymphocytes to TCRβδ-/- mice, which lack both TCRαβ+ and TCRγδ+ T cells, but have B cells, resulted in more severe inflammation in the liver and lungs than that seen in TCRα-/- recipients. Taken together, these studies demonstrate that TCRγδ+ T cells, but not B cells, in the TCRαβ-/- recipients mediate protection from disease induced by Scurfy T cells. The TCRγδ+ T cells in the TCRα-/- recipients of Scurfy cells markedly expanded and expressed a highly activated (CD44hi CD62Llo) phenotype, but did not produce IL-10. Surprisingly, the Scurfy T cells in these recipients produced more IL-10 and less IL-4 than Scurfy T cells transferred to RAG-/- or TCRβδ-/- recipients, suggesting that TCRγδ+ T cells may protect TCRα-/- recipients by modulating cytokine production by Scurfy T cells." @default.
- W1525702986 created "2016-06-24" @default.
- W1525702986 creator A5005119540 @default.
- W1525702986 creator A5067879929 @default.
- W1525702986 date "2014-05-01" @default.
- W1525702986 modified "2023-09-27" @default.
- W1525702986 title "γδ T cells protect TCRα deficient mice from the autoimmunity induced by scurfy lymphocytes (BA13P.118)" @default.
- W1525702986 doi "https://doi.org/10.4049/jimmunol.192.supp.177.4" @default.
- W1525702986 hasPublicationYear "2014" @default.
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